Tribendimidine

Drugbox
IUPAC_name = "N","N"'-bis(4-(1-dimethylamino)ethylideneaminophenyl)-1,4
-phenylene dimethylidyneamine

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CAS_number = 115103-15-6
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PubChem = 3086564
DrugBank =
C=28|H=32|N=6
molecular_weight = 452.594 g/mol
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Tribendimidine is a broad-spectrum anthelmintic agent developed in China, at the National Institute of Parasitic Diseases in Shanghai. It is a derivative of amidantel.cite journal |author=Keiser J, Shu-Hua X, Chollet J, Tanner M, Utzinger J |title=Evaluation of the in vivo activity of tribendimidine against "Schistosoma mansoni", "Fasciola hepatica", "Clonorchis sinensis", and "Opisthorchis viverrini" |journal=Antimicrob Agents Chemother |volume=51 |issue=3 |pages=1096–8 |year=2007 |pmid=17194822 |doi=10.1128/AAC.01366-06 [http://aac.asm.org/cgi/content/full/51/3/1096 Free full text] ]

In clinical trials, it was highly effective in treating ankylostomiasis, ascariasis and enterobiasis. [cite journal |author=Xiao SH, Hui-Ming W, Tanner M, Utzinger J, Chong W |title=Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China |journal=Acta Trop |volume=94 |issue=1 |pages=1–14 |year=2005 |pmid=15777691 |doi=10.1016/j.actatropica.2005.01.013] However, animal studies suggest it is ineffective in treating "Schistosoma mansoni" or "Fasciola hepatica" disease.

Tribendimidine is associated with Shandong Xinhua Pharmaceutical Company Limited in Zibo, Shandong, China.

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