Protein synthesis inhibitor
- Protein synthesis inhibitor
A protein synthesis inhibitor is a substance which stops or slows the growth or proliferation of cells by disrupting the processes that lead directly to the generation of new proteins.[cite web |url=http://cancerweb.ncl.ac.uk/cgi-bin/omd?protein+synthesis+inhibitor |title=Definition: protein synthesis inhibitor from Online Medical Dictionary |format= |work= |accessdate=] ]While a broad interpretation of this definition could be used to describe nearly any antibiotic, in practice it usually refers to substances that act at the ribosome level (either the ribosome itself or the translation factor),[cite web |url=http://ocw.mit.edu/OcwWeb/Biology/7-344Spring-2007/LectureNotes/index.htm |title=MIT OpenCourseWare | Biology | 7.344 Antibiotics, Toxins, and Protein Engineering, Spring 2007 | Lecture Notes |format= |work= |accessdate=] taking advantages of the major differences between prokaryotic and eukaryotic ribosome structure.]Toxins such as ricin also function via protein synthesis inhibition.[cite journal |author=Leonard JE, Grothaus CD, Taetle R |title=Ricin binding and protein synthesis inhibition in human hematopoietic cell lines |journal=Blood |volume=72 |issue=4 |pages=1357–63 |year=1988 |month=October |pmid=3167211 |doi= |url=http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=3167211] Ricin acts at the eukaryotic 60S. [PMID 3391162] ]Examples:
* Neomycin
* Geneticin, also called G418
ee also
* Protein biosynthesis
References
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2010.
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