Xanomeline

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ImageFile=Xanomeline.svg
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IUPACName=3-(4-hexoxy-1,2,5-thiadiazol-3-yl)-1-methyl-5,6-dihydro-2"H"-pyridine
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Section1=Chembox Identifiers
CASNo=131986-45-3
PubChem=60809
SMILES=CCCCCCOC1=NSN=C1C2=CCCN(C2)C
MeSHName=xanomeline
Section2=Chembox Properties
C=14|H=23|N=3|O=1|S=1
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Xanomeline is a muscarinic agonist selective for the M1 subtype.cite journal |author=Farde L, Suhara T, Halldin C, "et al" |title=PET study of the M1-agonists [11C] xanomeline and [11C] butylthio-TZTP in monkey and man |journal=Dementia |volume=7 |issue=4 |pages=187–95 |year=1996 |pmid=8835881 |doi= |url=] It has recently been studied in Europe for the cognitive and negative symptoms of Schizophrenia, and there were robust associated improvements in verbal learning and short-term memory. [Am J Psychiatry. 2008 Aug;165(8):1033-9. Epub 2008 Jul 1. LinksSelective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia.Shekhar A, Potter WZ, Lightfoot J, Lienemann J, Dubé S, Mallinckrodt C, Bymaster FP, McKinzie DL, Felder CC.]

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