- Ventricular remodeling
Ventricular remodeling refers to the changes in size, shape, and function of the heart after injury to the
left ventricle . The injury is typically due toacute myocardial infarction (usually transmural or ST segment elevation infarction), but may be from a number of causes that result in increased pressure or volume overload (forms of strain) on the heart. Chronichypertension ,congenital heart disease withintracardiac shunting , andvalvular heart disease may also lead to remodeling. After the insult occurs, a series of histopathological and structural changes occur in the left ventricular myocardium that lead to progressive decline in left ventricular performance. Ultimately, ventricular remodeling may result in diminished contractile (systolic ) function and reducedstroke volume .Medically speaking, "ventricular remodeling" implies a decline in function (even though the word "remodeling" usually implies improvement). The term "
reverse remodeling " in cardiology implies an improvement in ventricular mechanics and function after a remote injury.Pathophysiology
The
cardiac myocyte is the major cell involved in remodeling.Fibroblast s,collagen , the interstitium, and thecoronary vessel s to a lesser extent, also play a role. A common scenario for remodeling is after myocardial infarction. There is myocardialnecrosis (cell death) and disproportionate thinning of the heart. This thin, weakened area is unable to withstand the pressure and volume load on the heart in the same manner as the other healthy tissue. As a result there is dilatation of the chamber arising from the infarct region. The initial remodeling phase after a myocardial infarction results in repair of the necrotic area and scar formation that may, to some extent, be considered beneficial since there is an improvement in or maintenance of LV function andcardiac output . Over time, however, as the heart undergoes ongoing remodeling, it becomes less elliptical and more spherical. Ventricular mass and volume increase, which together adversely affect cardiac function. Eventually,diastolic function, or the heart's ability to relax between contractions may become impaired, further causing decline.Treatment
Many factors influence the time course and extent of remodeling, including the severity of the insult, secondary events (recurrent ischemia or infarction), neurohormonal activation, genetic factors and
gene expression , and treatment. Medications may attenuate remodeling. Angiotensin-converting enzyme (ACE) inhibitors have been consistently shown to decrease remodeling in animal models or transmural infarction and chronic pressure overload. Clinical trials have shown that ACE inhibitor therapy after myocardial infarction leads to improved myocardial performance, improvedejection fraction , and decreased mortality compared to patients treated with placebo. Likewise, inhibition ofaldosterone , either directly or indirectly, leads to improvement in remodeling. [ [http://content.nejm.org/cgi/content/full/348/14/1309 NEJM - Eplerenone, a Selective Aldosterone Blocker, in Patients with Left Ventricular Dysfunction after Myocardial Infarction ] ] Early correction of congenital heart defects, if appropriate, may prevent remodeling, as will treatment of chronichypertension orvalvular heart disease . Often, reverse remodeling, or improvement in left ventricular function, will also be seen.ee also
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References
(1) Pitt B, Remme W, Zannad F, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003; 348:1309-21. (http://content.nejm.org/cgi/content/full/348/14/1309)
*Cardiac remodeling--concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J Am Coll Cardiol. 2000 Mar 1;35(3):569-82.
*Sutton, MG, Sharpe, N. Left ventricular remodeling after myocardial infarction: pathophysiology and therapy. Circulation 2000; 101:2981
*Konstam, MA, Kronenberg, MW, Rousseau, MF, et al. Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dilatation in patients with asymptomatic systolic dysfunction. SOLVD (Studies of Left Ventricular Dysfunction) Investigators. Circulation 1993; 88:2277.
*Greenberg, B, Quinones, MA, Koilpillai, C, et al. Effects of long-term enalapril therapy on cardiac structure and function in patients with left ventricular dysfunction. Results of the SOLVD echocardiography substudy. Circulation 1995; 91:2573.
*Doughty, RN, Whalley, GA, Gamble, G, et al. Left ventricular remodeling with carvedilol in patients with congestive heart failure due to ischemic heart disease. J Am Coll Cardiol 1997; 29:1060.
*Kheradvar, A, Gorman, RC, Gorman, JH 3rd, Zeeshan, A, Gharib, M. Evaluation of isovolumic relaxation phase in the process of ventricular remodeling following myocardial infarction. Conf Proc IEEE Eng Med Biol Soc. 2004;5:3654-7.
*Cohn JN. Cardiac Remodeling, UpToDate v.13.1 www.uptodateonline.com. Accessed July 17, 2005.
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