Clopenthixol

Clopenthixol
cis,trans-mixture
Systematic (IUPAC) name
cis,trans-2-[4-[3-(2-chlorothioxanthen-9-ylidene) propyl]piperazin-1-yl]ethanol
Clinical data
Pregnancy cat.  ?
Legal status  ?
Routes Oral
Identifiers
CAS number 982-24-1 N
ATC code N05AF02
PubChem CID 12454
ChemSpider 11945 N
UNII FLE878A8ZI N
KEGG D02613 N
Chemical data
Formula C22H25ClN2OS 
Mol. mass 400.965 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Clopenthixol (Sordinol), also known as clopentixol, is a typical antipsychotic drug of the thioxanthene class. It was introduced by Lundbeck in 1961.[1]

Clopenthixol is a racemic mixture of cis and trans isomers. Zuclopenthixol, the pure cis isomer, was later introduced by Lundbeck in 1962,[2] and has been much more widely used. Both drugs are equally effective as antipsychotics and have similar adverse effect profiles, but clopenthixol is half as active on a milligram-to-milligram basis and appears to produce more sedation in comparison.[3]

See also

References

  1. ^ Sneader, Walter (2005). Drug discovery: a history. New York: Wiley. p. 410. ISBN 0-471-89980-1. http://books.google.com/?id=Cb6BOkj9fK4C&lpg=PA410&pg=PA410#v=onepage. 
  2. ^ José Miguel Vela; Helmut Buschmann; Jörg Holenz; Antonio Párraga; Antoni Torrens (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. p. 516. ISBN 3-527-31058-4. http://books.google.com/?id=yXD4QA-Y_Z0C&lpg=PA520&dq=thioxanthene%201965%20pfizer&pg=PA516#v=onepage&q=. 
  3. ^ Gravem A, Engstrand E, Guleng RJ (November 1978). "Cis(Z)-clopenthixol and clopenthixol (Sordinol) in chronic psychotic patients. A double-blind clinical investigation". Acta Psychiatr Scand 58 (5): 384–8. doi:10.1111/j.1600-0447.1978.tb03570.x. PMID 362830. 

External links