HMG-box

Pfam_box
Symbol = PF00505
Name = HMG (high mobility group) box

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width = 300px
caption = NMR structure of the HMG-box domain of the LEF1 protein (rainbow colored, N-terminus = blue, C-terminus = red) complexed with DNA (brown) based on the PDB|2LEF coordinates.
Pfam = PF00505
InterPro = IPR009071
SMART=
PROSITE=
SCOP = 1hsm
TCDB =
OPM family =
OPM protein =
PDB = PDB2|1aab, PDB2|1cg7, PDB2|1ckt, PDB2|1e7j, PDB2|1gt0, PDB2|1hme, PDB2|1hmf, PDB2|1hry, PDB2|1hrz, PDB2|1hsm, PDB2|1hsn, PDB2|1i11, PDB2|1j3x, PDB2|1j46, PDB2|1j47, PDB2|1j5n, PDB2|1k99, PDB2|1lwm, PDB2|1nhm, PDB2|1nhn, PDB2|1o4x, PDB2|1qrv, PDB2|1s9m, PDB2|1sx9, PDB2|1v64, PDB2|1wgf, PDB2|1wxl, PDB2|2crj, PDB2|2cs1, PDB2|2lefThe HMG-box (High Mobility Group box) is a protein domain which is involved in DNA binding.cite journal | author = Stros M, Launholt D, Grasser KD | title = The HMG-box: a versatile protein domain occurring in a wide variety of DNA-binding proteins | journal = Cell. Mol. Life Sci. | volume = 64 | issue = 19-20 | pages = 2590–606 | year = 2007 | month = October | pmid = 17599239 | doi = 10.1007/s00018-007-7162-3 | url = | issn = ]

tructure

The structure of the HMG-box domain contains three alpha helices separated by loops (see figure to the right).cite journal | author = Thomas JO | title = HMG1 and 2: architectural DNA-binding proteins | journal = Biochem. Soc. Trans. | volume = 29 | issue = Pt 4 | pages = 395–401 | year = 2001 | month = August | pmid = 11497996 | doi = | url = http://www.biochemsoctrans.org/bst/029/0395/bst0290395.htm | issn = ]

Function

HMG-box containing proteins only bind non-B-type DNA conformations (kinked or unwound) with high affinity. HMG-box domains are found in high mobility group proteins, which are involved in the regulation of DNA-dependent processes such as transcription, replication, and DNA repair, all of which require changing the conformation of chromatin.

References

External links

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