Triosephosphate isomerase

Triosephosphate isomerase

Protbox
Name=Triosephosphate isomerase 1
Photo=Beta-barrel.pngCaption=The structure of human TPI PDB|1WYI
width=200
AltSymbols=TIM
HGNCid=12009
Symbol=TPI1
Chromosome=12
Arm=p
Band=13
LocusSupplementaryData=
Gene=
Gene_type=
Protein_length=
Molecular_weight=
Structure=
Type=
Functions=
Domains=
Motifs=
Alternative_products=
Catalytic_activity=
Cofactors=
Enzyme_regulation=
Km=
Vmax=
Biophysicochemical_properties=
Diseases=
Pharmaceuticals=
Biotechnology=
Taxa=
Cells=
Location=
Mods=
Names=
Pathways=
Interactions=
Actions=
Agonists=
Antagonists=
Accession_numbers=
OMIM=190450
EntrezGene=7167
RefSeq=NM_000365
UniProt=P60174
PDB =
ECnumber=5.3.1.1
Codes=
Review=
Pages=

Triose-phosphate isomerase (TPI or TIM), is an enzyme (EC number|5.3.1.1) that catalyzes the reversible interconversion of the triose phosphate isomers dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate.

Enzymatic Reaction
foward_enzyme=triose phosphate isomerase
reverse_enzyme=triose phosphate isomerase
substrate=Dihydroxyacetone phosphate
product=D-glyceraldehyde 3-phosphate
reaction_direction_(foward/reversible/reverse)=reversible
minor_foward_substrate(s)=
minor_foward_product(s)=
minor_reverse_substrate(s)=
minor_reverse_product(s)=
substrate_

product_

TPI plays an important role in glycolysis and is essential for efficient energy production. TPI has been found in nearly every organism searched for the enzyme, including animals such as mammals and insects as well as in fungi, plants and bacteria. However, some bacteria that do not perform glycolysis, like ureaplasmas, lack TPI.

In humans, deficiencies in TPI are associated with a progressive, severe neurological disorder called Triose Phosphate Isomerase deficiency.

Triose phosphate isomerase is a highly efficient enzyme, performing the reaction billions of times faster than it would occur naturally in solution. The reaction is so efficient it is limited only by the rate the substrate can diffuse into the enzyme's active site.

tructure

Triose phosphate isomerase is a dimer of identical subunits, each of which is made up of about 250 amino acid residues. The three-dimensional structure of a subunit contains eight α-helices (blue and red) on the outside and eight parallel β-strands on the inside (violet and yellow). This structural motif is called an αβ-barrel, or a TIM-barrel, and is by far the most commonly observed protein fold. The active site of this enzyme is in the center of the barrel. A glutamic acid residue as well as a histidine are involved in the catalytic mechanism. The sequence around the active site residue is conserved in all known triose phosphate isomerases.


ee also

* TIM barrel
* Triose Phosphate Isomerase deficiency
* TPI1

References

http://pdbdev.sdsc.edu:48346/pdb/molecules/pdb50_6.html


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Triosephosphate isomerase deficiency — Infobox Disease Name = Triosephosphate isomerase deficiency Caption = DiseasesDB = 30116 ICD10 = ICD10|D|55|2|d|55 ICD9 = ICD9|282.3 ICDO = OMIM = 190450 MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID = Triosephosphate isomerase deficiency …   Wikipedia

  • triosephosphate isomerase — An isomerizing enzyme that catalyzes the reversible interconversion of d glyceraldehyde 3 phosphate and dihydroxyacetone phosphate, a reaction of importance in glycolysis and gluconeogenesis; a deficiency of this enzyme will result in hemolytic …   Medical dictionary

  • Triosephosphat-Isomerase-Defizienz — Klassifikation nach ICD 10 D55.2 Anämie durch Störungen glykolytischer Enzyme Triosephosphat Isomerase Mangel …   Deutsch Wikipedia

  • Mannose phosphate isomerase — mannose 6 phosphate isomerase Identifiers Symbol MPI, PMI Entrez 4351 HUGO …   Wikipedia

  • phosphotriose isomerase — SYN: triosephosphate isomerase …   Medical dictionary

  • TPI1 — Triosephosphate isomerase 1, also known as TPI1, is a human gene.cite web | title = Entrez Gene: TPI1 triosephosphate isomerase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=7167| accessdate = ] PBB… …   Wikipedia

  • Heterozygote advantage — A heterozygote advantage (heterozygous advantage) describes the case in which the heterozygote genotype has a higher relative fitness than either the homozygote dominant or homozygote recessive genotype. The specific case of heterozygote… …   Wikipedia

  • Methylglyoxal pathway — The methylglyoxal pathway is an offshoot of glycolysis found in some prokaryotes, which converts glucose into methylglyoxal and then into pyruvate. However unlike glycolysis the methylglyoxal pathway does not produce adenosine triphosphate, ATP.… …   Wikipedia

  • PDIA3 — protein disulfide isomerase family A, member 3 Identifiers Symbol PDIA3 Alt. symbols GRP58 Entrez 2923 …   Wikipedia

  • НЕДОСТАТОЧНОСТЬ ФЕРМЕНТОВ — мед. Синдромы врождённых нарушений обмена веществ встречаются редко, но оказывают значительное влияние на физическое, интеллектуальное, психическое развитие и качество жизни (например, фенилкетонурия, гомоцистинурия, гликогенозы, синдромы ломкой… …   Справочник по болезням

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”