Trimebutine

Trimebutine

Systematic (IUPAC) name
2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	39133-31-8
ATC code	A03AA05
PubChem	CID 5573
UNII	QZ1OJ92E5R Y
Chemical data
Formula	C22H29NO5
Mol. mass	387.47 g/mol
Y(what is this?)  (verify)

Trimebutine is a drug with antimuscarinic and weak mu opioid agonist effects.^[1] The maleic acid salt of trimebutine is marketed under the trademark of Debridat, Recutin, Polybutin,^[2] or Modulon for treatment of irritable bowel syndrome and other gastrointestinal disorders. The major product from drug metabolism of trimebutine in human beings is nor-trimebutine,^[3] which comes from removal of one of the methyl groups attached to nitrogen. Both Trimebutine and its metabolite are commercially available.

References

1. ^ Kaneto H, Takahashi M, Watanabe J. The opioid receptor selectivity for trimebutine in isolated tissues experiments and receptor binding studies. Journal of Pharmacobiodynamics. 1990 Jul;13(7):448-53. PMID 1963196
2. ^ Ok Hwa Jhee, Yun Sik Lee, Leslie M. Shaw, Yong Cheol Jeon, Min Ho Lee, Seung Hoon Lee and Ju Seop Kang The Pharmacokinetic and bioequivalence evaluation of two formulations of 100 mg trimebutine maleate (Recutin and Polybutin) in healthy male volunteers using the LC–MS/MS method. Clinica Chimica Acta. 2007 Jan;375(1-2):69-75. PMID 16854404
3. ^ F.J. Roman, S. Lanet, J. Hamon, G. Brunelle, A. Maurin, P. Champeroux, S. Richard, N. Alessandri, and M. Gola Pharmacological Properties of Trimebutine and N-Monodesmethyltrimebutine. The Journal of Pharmacology and Experimental Therapeutics 1999;289:1391–1397. PMID 10336531

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