JTE-907

Drugbox
IUPAC_name = N-(benzo [1,3] dioxol-5-ylmethyl)-7-methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3-carboxamide


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chemical_formula = |C=24|H=26|N=2|O=6
molecular_weight = 438.472
smiles = c4c3OCOc3ccc4CNC(=O)c(cc2ccc1OC)c(=O)nc2c1OCCCCC
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JTE-907 is a drug used in scientific research which acts as a selective CB₂ inverse agonist. [Iwamura H, Suzuki H, Ueda Y, Kaya T, Inaba T. In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor. "Journal of Pharmacology and Experimental Therapeutics". 2001 Feb;296(2):420-5. PMID 11160626] [Raitio KH, Savinainen JR, Vepsäläinen J, Laitinen JT, Poso A, Järvinen T, Nevalainen T. Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists. "Journal of Medicinal Chemistry". 2006 Mar 23;49(6):2022-7. PMID 16539390] It has antiinflammatory effects in animal studies, [Ueda Y, Miyagawa N, Matsui T, Kaya T, Iwamura H. Involvement of cannabinoid CB(2) receptor-mediated response and efficacy of cannabinoid CB(2) receptor inverse agonist, JTE-907, in cutaneous inflammation in mice. "European Journal of Pharmacology". 2005 Sep 27;520(1-3):164-71. PMID 16153638] thought to be mediated by an interaction between the CB₂ receptor and IgE. [Ueda Y, Miyagawa N, Wakitani K. Involvement of cannabinoid CB2 receptors in the IgE-mediated triphasic cutaneous reaction in mice. "Life Sciences". 2007 Jan 9;80(5):414-9. PMID 17055000]

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