Cetilistat

Cetilistat
Cetilistat
Systematic (IUPAC) name
2-(hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 282526-98-1
ATC code None
PubChem CID 9952916
UNII LC5G1JUA39 YesY
KEGG D09208 YesY
Chemical data
Formula C25H39NO3 
Mol. mass 401.582 g/mol
SMILES eMolecules & PubChem
 YesY(what is this?)  (verify)

Cetilistat is a drug designed to treat obesity. It acts in the same way as the older drug orlistat (Xenical) by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested.[1]

In human trials, cetilistat was shown to produce similar weight loss to orlistat, but also produced similar side effects such as oily, loose stools, fecal incontinence, frequent bowel movements, and flatulence.[2][3] It is likely that the same precautions would apply in that absorption of fat-soluble vitamins and other fat-soluble nutrients may be inhibited, requiring vitamin supplements to be used to avoid deficiencies.

Cettilistat has completed Phase 1 and 2 trials in the West and is currently in Phase 3 trials in Japan where it is partenered with Takeda.[4] Norgina BV has now acquired the full global rights to Cettilistat from Alizyme after the latter went into administration.[5]

See also

Anti-obesity medication

References

  1. ^ Yamada Y, Kato T, Ogino H, Ashina S, Kato K. Cetilistat (ATL-962), a novel pancreatic lipase inhibitor, ameliorates body weight gain and improves lipid profiles in rats. Hormone and Metabolic Research. 2008 Aug;40(8):539-43. PMID 18500680
  2. ^ Kopelman P, Bryson A, Hickling R, Rissanen A, Rossner S, Toubro S, Valensi P. Cetilistat (ATL-962), a novel lipase inhibitor: a 12-week randomized, placebo-controlled study of weight reduction in obese patients. International Journal of Obesity (London). 2007 Mar;31(3):494-9. PMID 16953261
  3. ^ Padwal R. Cetilistat, a new lipase inhibitor for the treatment of obesity. Current Opinion in Investigational Drugs. 2008 Apr;9(4):414-21. PMID 18393108
  4. ^ http://www.alizyme.com/alizyme/products/cetilistat/
  5. ^ http://www.norgine.com/downloads/pr_archive/Norgine%20aquires%20cetilistat_2.pdf
v · d · eAntiobesity agents/Anorectics (A08)
Central
4-Methylamphetamine • Amfecloral • Amfepentorex • Amfepramone • Aminorex • Amphetamine • Amphetaminil • Atomoxetine • Benfluorex‡ • Benzphetamine • Bupropion • Cathine • Cathinone • Chlorphentermine • Ciclazindol • Clobenzorex • Cloforex • Clominorex • Clortermine • Dexfenfluramine • Dextroamphetamine • Dextromethamphetamine • Dexmethylphenidate • Difemetorex • Dimethylcathinone • Diphemethoxidine • Ephedrine • Ephedra • Ethylamphetamine • Etolorex • Fenbutrazate • Fencamfamine • Fenethylline • Fenfluramine (+phentermine) • Fenproporex • Fludorex • Fluminorex • Furfenorex • Indanorex • Khat • Levopropylhexedrine • Lisdexamfetamine • Manifaxine • Mazindol • Mefenorex • Methamphetamine • Methylphenidate • Norfenfluramine • Pemoline • Pentorex (Phenpentermine) • Phendimetrazine • Phenethylamine • Phenmetrazine • Phentermine • Phenylpropanolamine • Pipradrol • Prolintane • Propylhexedrine • Pseudoephedrine • Pyrovalerone • Radafaxine • Reboxetine • Setazindol • Sibutramine • Synephrine • Tesofensine • Viloxazine • Xylopropamine • Zylofuramine
Cannabinoids
Ibipinabant • Otenabant • Rimonabant • Surinabant • Taranabant
Others
5-HTP • Galactomannan (Guar Gum) • Glucomannan • L-DOPA • L-Phenylalanine • L-Tryptophan • L-Tyrosine • Lorcaserin • Lu AA-33810 • Metformin • Naltrexone • Naloxone • Oxyntomodulin • P57 • Peptide YY • Topiramate • Yohimbine (Yohimbe) • Zonisamide
Peripheral
Cetilistat • Dinitrophenol • Oleoyl-Estrone • Orlistat • Simmondsin • Sterculia

M: NUT

cof, enz, met

noco, nuvi, sysi/epon, met

drug(A8/11/12)

Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • Cetilistat — Général Nom IUPAC 2 hexadécoxy 6 méthyl 3,1 benzoxazine 4 one No CAS …   Wikipédia en Français

  • Cétilistat — Général Nom IUPAC 2 hexadécoxy 6 méthyl 3,1 benzoxazine 4 one No CAS …   Wikipédia en Français

  • 282526-98-1 — Cetilistat Cetilistat Général Nom IUPAC 2 hexadécoxy 6 méthyl 3,1 benzoxazine 4 one No CAS …   Wikipédia en Français

  • Anti-obesity medication — Orlistat (Xenic …   Wikipedia

  • Amphetamine — For other uses, see Amphetamine (disambiguation). Amphetamine Systematic (IUPAC) name …   Wikipedia

  • Stimulant — Ritalin Slow Release (SR) 20 mg tablets. Stimulants (also referred to as psychostimulants) are psychoactive drugs which induce temporary improvements in either mental or physical function or both. Examples of these kinds of effects may include… …   Wikipedia

  • Benzphetamine — Systematic (IUPAC) name (2S) N benzyl N methyl 1 phenylpropan 2 amine …   Wikipedia

  • Orlistat — Packaging of orlistat (Xenical) 120 mg capsules, as sold in Canada. Systematic (IUPAC) name …   Wikipedia

  • Cathine — Not to be confused with caffeine, a compound found in coffee and tea. Cathine Systematic ( …   Wikipedia

  • Anorectic — An anorectic or anorexic (from the Greek an = without and orexis = appetite ), also known as anorexigenic or appetite suppressant, is a dietary supplement and/or drug which reduces appetite, food consumption, and as a result, causes weight loss… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”