Chorionic gonadotropin beta

Chorionic gonadotropin, beta polypeptide
PDB rendering based on 1hcn.
Available structures PDB 1HCN, 1HRP, 1QFW, 1XUL
Identifiers
Symbols	CGB; CGB3; CGB5; CGB7; CGB8; hCGB
External IDs	OMIM: 118860 HomoloGene: 37338 GeneCards: CGB Gene
Gene Ontology Molecular function • hormone activity Cellular component • extracellular region • soluble fraction Biological process • apoptosis • signal transduction • cell-cell signaling • female gamete generation • peptide hormone processing • cellular nitrogen compound metabolic process • hormone biosynthetic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1082	16866
Ensembl	ENSG00000104827	ENSMUSP00000072276
UniProt	P01233	Q3UUG9
RefSeq (mRNA)	NM_000737.2	NM_008497
RefSeq (protein)	NP_000728.1	NM_008497
Location (UCSC)	Chr 19: 49.53 – 49.53 Mb	Chr chr7: 52.68 – 52.68 Mb
PubMed search	[1]	[2]

Choriogonadotropin subunit beta (CG-beta) also known as chorionic gonadotrophin chain beta is a protein that in humans is encoded by the CGB gene.^[1][2][3]

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and a unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene.^[1]

References

1. ^ ^{a b} "Entrez Gene: chorionic gonadotropin". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=94115. 
2. ^ Fiddes JC, Goodman HM (August 1980). "The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region". Nature 286 (5774): 684–7. doi:10.1038/286684a0. PMID 6774259. 
3. ^ Policastro P, Ovitt CE, Hoshina M, Fukuoka H, Boothby MR, Boime I (October 1983). "The beta subunit of human chorionic gonadotropin is encoded by multiple genes". J. Biol. Chem. 258 (19): 11492–9. PMID 6194155. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.