CFU-GEMM

CFU-GEMM
CFU-GEMM
Code TH H2.00.04.3.02008

CFU-GEMM is a colony forming unit that generates myeloid cells.

CFU-GEMM cells are multipotential progenitor cells.[1][2]

The "GEMM" stands for ""granulocyte, erythrocyte, monocyte, megakaryocyte".[3]

CFU-GEMM gives rise to CFU-GM.

It has been suggested that eosinophils do not derive from the common myeloid progenitor.[4]

References

  1. ^ Carow CE, Hangoc G, Broxmeyer HE (February 1993). "Human multipotential progenitor cells (CFU-GEMM) have extensive replating capacity for secondary CFU-GEMM: an effect enhanced by cord blood plasma". Blood 81 (4): 942–9. PMID 7679010. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=7679010. 
  2. ^ Roodman GD, LeMaistre CF, Clark GM, Page CP, Newcomb TF, Knight WA (August 1987). "CFU-GEMM correlate with neutrophil and platelet recovery in patients receiving autologous marrow transplantation after high-dose melphalan chemotherapy". Bone Marrow Transplant. 2 (2): 165–73. PMID 3332164. 
  3. ^ "Hem I WBC Morphology and Physiology". http://www.clt.astate.edu/wwilliam/hem_i_wbc_morphology_and_physiology.htm. Retrieved 2008-12-30. [dead link]
  4. ^ Mori Y, Iwasaki H, Kohno K, et al. (January 2009). "Identification of the human eosinophil lineage-committed progenitor: revision of phenotypic definition of the human common myeloid progenitor". J. Exp. Med. 206 (1): 183–93. doi:10.1084/jem.20081756. PMC 2626675. PMID 19114669. http://www.jem.org/cgi/pmidlookup?view=long&pmid=19114669. 
v · d · eMyeloid lineage - Blood (WBC and RBC)
Cellular/
HSCs
Myeloid/
CFU-GEMM
CFU-GM
CFU-DL
Common
CFU-Baso
CFU-Eos
CFU-Meg
CFU-E
CFU-Mast
Noncellular

M: MYL

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns
v · d · eMyeloid physiology
Hematopoiesis
Myelopoiesis
(CFU-GEMM)
CFU-GM
General
Extramedullary hematopoiesis
Hemostasis
Coagulation (Fibrinolysis) · Clot retraction · Platelet adhesiveness
Other
Erythrocyte aggregation

M: MYL

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns
v · d · eHuman cell types / list derived primarily from mesoderm
Paraxial

bone: Osteoblast → Osteocyte

cartilage: Chondroblast → Chondrocyte

Fibroblast → Fibrocyte

muscle: Myoblast → Myocyte · Myosatellite cell · Tendon cell · Cardiac muscle cell

adipose: Lipoblast → Adipocyte
Digestive system
Intermediate

Angioblast → Endothelial cell · Mesangial cell (Intraglomerular, Extraglomerular) · Juxtaglomerular cell · Macula densa cell

Stromal cell → Interstitial cell → Telocytes

Simple epithelial cell → Podocyte · Kidney proximal tubule brush border cell
Sertoli cell · Leydig cell · Granulosa cell · Peg cell · (spermatozoon and ovum are germ cells)
Lateral plate/
hemangioblast
Blood/immune
(HSC)
see lymphocytes
Myeloid (CFU-GEMM)
see myeloid cells

M: BON/CAR

anat(c/f/k/f, u, t/p, l)/phys/devp/cell

noco/cong/tumr, sysi/epon, injr

proc, drug(M5)

M: URI

anat/phys/devp/cell

noco/acba/cong/tumr, sysi/epon, urte

proc/itvp, drug (G4B), blte, urte

M: VAS

anat(a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot

noco/syva/cong/lyvd/tumr, sysi/epon, injr

proc, drug(C2s+n/3/4/5/7/8/9)

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