- Crystal arthropathy
-
Crystal arthropathy Classification and external resources ICD-10 M10-M11 ICD-9 712 Crystal arthropathy refers to a type of arthropathy characterized by accumulation of crystals in joints. Polarizing microscopy and application of other crystallographic techniques have improved identification of different microcrystals including monosodium urate, calcium-pyrophosphate dihydrate, calcium hydroxyapatite, and calcium oxalate.[1]
Types include:
Name Substance Birefringence Gout[2] accumulation of uric acid negative Chondrocalcinosis[3] accumulation of calcium pyrophosphate positive Contents
Risk Factors
- Obesity
- Renal failure
- Hyperphosphatemia
- Hyperparathyroidism
- Hypercalcemia
- Tissue damage (dystrophic calcification)
Causes
- Deposition of crystals in joints
- Calcium-pyrophosphate dihydrate crystal formation:
- Increased production of inorganic pyrophosphate
- Decreased levels of pyrophosphatase in cartilage
- Decreased levels of cartilage glycosaminoglycans
- Hyperparathyroidism
- Hemochromatosis
- Hypophosphatasia
- Hypomagnesemia
- Hydroxyapatite deposition:
- Tissue damage
- Hyperparathyroidism
- Hypercalcemia
- Hyperphosphatemia
- Calcium Oxalate deposition:
- Enhanced production of oxalic acid due to enzyme defect
- Poor excretion of oxalic acid in renal failure
- Excessive ascorbic acid intake in renal failure
Differential Diagnosis
- Infectious arthritis
- Gout
- Type IIa hyperlipoproteinemia
- Amyloidosis
- Multicentric reticulohistiocytosis
- Hyperparathyroidism
- Spondyloarthropathy
- Rheumatoid arthritis
- Fibromyalgia
References
- ^ Neil W. Mcgill (2000). "Gout and other crystal-associated arthropathies". Ballieri's Clinical Rheumatology 14 (3): 445–460.
- ^ Choi H (May 2006). "Epidemiology of crystal arthropathy". Rheum. Dis. Clin. North Am. 32 (2): 255–73, v. doi:10.1016/j.rdc.2006.03.002. PMID 16716879. http://linkinghub.elsevier.com/retrieve/pii/S0889-857X(06)00025-1.
- ^ Canhão H, Fonseca JE, Leandro MJ, et al. (2001). "Cross-sectional study of 50 patients with calcium pyrophosphate dihydrate crystal arthropathy". Clin. Rheumatol. 20 (2): 119–22. doi:10.1007/s100670170081. PMID 11346223. http://link.springer.de/link/service/journals/10067/bibs/1020002/10200119.htm.
Musculoskeletal disorders: Arthropathies (M00–M19, 711–719) Arthritis
(monoarthritis/
polyarthritis)NoninfectiousRheumatoid arthritis: Juvenile idiopathic arthritis · Adult-onset Still's disease · Felty's syndromeNoninflammatoryOther hemorrhage (Hemarthrosis) · pain (Arthralgia) · Osteophyte · villonodular synovitis (Pigmented villonodular synovitis) · Joint stiffnessM: JNT
anat(h/c, u, t, l)/phys
noco(arth/defr/back/soft)/cong, sysi/epon, injr
proc, drug(M01C, M4)
Categories:- Inflammatory polyarthropathies
- Medicine stubs
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