D-alanine—alanyl-poly(glycerolphosphate) ligase

D-alanine—alanyl-poly(glycerolphosphate) ligase
D-alanine-alanyl-poly(glycerolphosphate) ligase
Identifiers
EC number 6.3.2.16
CAS number 9046-58-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a D-alanine-alanyl-poly(glycerolphosphate) ligase (EC 6.3.2.16) is an enzyme that catalyzes the chemical reaction

ATP + D-alanine + alanyl-poly(glycerolphosphate) \rightleftharpoons ADP + phosphate + D-alanyl-alanyl-poly(glycerolphosphate)

The 3 substrates of this enzyme are ATP, D-alanine, and alanyl-poly(glycerolphosphate), whereas its 3 products are ADP, phosphate, and D-alanyl-alanyl-poly(glycerolphosphate).

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is D-alanine:alanyl-poly(glycerolphosphate) ligase (ADP-forming). Other names in common use include D-alanyl-alanyl-poly(glycerolphosphate) synthetase, D-alanine:membrane-acceptor ligase, D-alanylalanylpoly(phosphoglycerol) synthetase, D-alanyl-poly(phosphoglycerol) synthetase, and D-alanine-membrane acceptor-ligase. This enzyme participates in d-alanine metabolism.

References

  • Reusch VM Jr, Neuhaus FC (1971). "D-Alanine: membrane acceptor ligase from Lactobacillus casei". J. Biol. Chem. 246 (20): 6136–43. PMID 4399593. 
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