- D-alanine—poly(phosphoribitol) ligase
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D-alanine-poly(phosphoribitol) ligase Identifiers EC number 6.1.1.13 CAS number 9023-65-8 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a D-alanine—poly(phosphoribitol) ligase (EC 6.1.1.13) is an enzyme that catalyzes the chemical reaction
- ATP + D-alanine + poly(ribitol phosphate)
AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)
The 3 substrates of this enzyme are ATP, D-alanine, and poly(ribitol phosphate), whereas its 3 products are AMP, diphosphate, and O-D-alanyl-poly(ribitol phosphate).
This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is D-alanine:poly(phosphoribitol) ligase (AMP-forming). Other names in common use include D-alanyl-poly(phosphoribitol) synthetase, D-alanine: membrane acceptor ligase, D-alanine-D-alanyl carrier protein ligase, D-alanine-membrane acceptor ligase, and D-alanine-activating enzyme. This enzyme participates in d-alanine metabolism.
References
- BADDILEY J, NEUHAUS FC (1960). "The enzymic activation of D-alanine". Biochem. J. 75: 579–87. PMC 1204514. PMID 13795638. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1204514.
- Reusch VM Jr, Neuhaus FC (1971). "D-Alanine: membrane acceptor ligase from Lactobacillus casei". J. Biol. Chem. 246 (20): 6136–43. PMID 4399593.
- Perego M, Glaser P, Minutello A, Strauch MA, Leopold K, Fischer W (1995). "Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis. Identification of genes and regulation". J. Biol. Chem. 270 (26): 15598–606. doi:10.1074/jbc.270.26.15598. PMID 7797557.
- Heaton MP, Neuhaus FC (1994). "Role of the D-alanyl carrier protein in the biosynthesis of D-alanyl-lipoteichoic acid". J. Bacteriol. 176 (3): 681–90. PMC 205105. PMID 8300523. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=205105.
- Debabov DV, Heaton MP, Zhang Q, Stewart KD, Lambalot RH, Neuhaus FC (1996). "The D-Alanyl carrier protein in Lactobacillus casei: cloning, sequencing, and expression of dltC". J. Bacteriol. 178 (13): 3869–76. PMC 232648. PMID 8682792. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232648.
Enzymes: CO CS and CN ligases (EC 6.1-6.3) 6.1: Carbon-Oxygen Aminoacyl tRNA synthetase (Tyrosine, Tryptophan, Threonine, Leucine, Isoleucine, Lysine, Alanine, Valine, Methionine, Serine, Aspartate, D-alanine-poly(phosphoribitol) ligase, Glycine, Proline, Cysteine, Glutamate, Glutamine, Arginine, Phenylalanine, Histidine, Asparagine, Aspartate, Glutamate, Lysine)6.2: Carbon-Sulfur Succinyl coenzyme A synthetase - Acetyl Co-A synthetase - Long fatty acyl CoA synthetase6.3: Carbon-Nitrogen Glutamine synthetase - Ubiquitin ligase (Cullin, Von Hippel-Lindau tumor suppressor, UBE3A, Mdm2, Anaphase-promoting complex, UBR1) - Glutathione synthetase - CTP synthase - Adenylosuccinate synthase - Argininosuccinate synthetase - Holocarboxylase synthetase - GMP synthase - Asparagine synthetase - Carbamoyl phosphate synthetase (I, II) - Gamma-glutamylcysteine synthetaseLigases: carbon-carbon ligases (EC 6.4) Biotin dependent carboxylase Other 6.5: Phosphoric Ester 6.6: Nitrogen-Metal This ligase article is a stub. You can help Wikipedia by expanding it. - ATP + D-alanine + poly(ribitol phosphate)
