DCTN5

DCTN5
Dynactin 5 (p25)
Identifiers
Symbols DCTN5;
External IDs OMIM612962 HomoloGene10998 GeneCards: DCTN5 Gene
Orthologs
Species Human Mouse
Entrez 84516 59288
Ensembl ENSG00000166847 ENSMUSG00000030868
UniProt Q9BTE1 Q9QZB9
RefSeq (mRNA) n/a NM_021608.3
RefSeq (protein) n/a NP_067621.3
Location (UCSC) Chr 16:
23.65 – 23.68 Mb
Chr 7:
129.28 – 129.29 Mb
PubMed search [1] [2]
This box: view · protein that in humans is encoded by the DCTN5 gene.[1]

This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.[1]

References

Further reading

Eckley, D. M.; Gill, S. R.; Melkonian, K. A.; Bingham, J. B.; Goodson, H. V.; Heuser, J. E.; Schroer, T. A. (1999). "Analysis of Dynactin Subcomplexes Reveals a Novel Actin-Related Protein Associated with the Arp1 Minifilament Pointed End". The Journal of cell biology 147 (2): 307–320. PMC 2174220. PMID 10525537. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2174220.  edit Parisi, G.; Fornasari, M.; Echave, J. (2004). "Dynactins p25 and p27 are predicted to adopt the L?H fold". FEBS Letters 562 (1–3): 1–4. doi:10.1016/S0014-5793(04)00165-6. PMID 15043994.  edit Burton, P. R.; Clayton, D. G.; Cardon, L. R.; Craddock, N.; Deloukas, P.; Duncanson, A.; Kwiatkowski, D. P.; McCarthy, M. I. et al. (2007). "Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls". Nature 447 (7145): 661–678. doi:10.1038/nature05911. PMC 2719288. PMID 17554300. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2719288.  edit


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  • Dynactin — or Dynein activator complex is a multi subunit protein found in eukaryotic cells that aids in bidirectional intracellular transport by binding to dynein and Kinesin II and linking them to the organelle or vesicle to be transported.[1][2] Contents …   Wikipedia

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