Discoidin domain-containing receptor 2

Discoidin domain-containing receptor 2
Discoidin domain receptor tyrosine kinase 2

Rendering based on PDB 2WUH.
Identifiers
Symbols DDR2; MIG20a; NTRKR3; TKT; TYRO10
External IDs OMIM191311 MGI1345277 HomoloGene68505 GeneCards: DDR2 Gene
EC number 2.7.10.1
RNA expression pattern
PBB GE DDR2 205168 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4921 18214
Ensembl ENSG00000162733 ENSMUSG00000026674
UniProt Q16832 Q62371
RefSeq (mRNA) NM_001014796.1 NM_022563.2
RefSeq (protein) NP_001014796.1 NP_072075.2
Location (UCSC) Chr 1:
162.6 – 162.75 Mb
Chr 1:
171.9 – 172.04 Mb
PubMed search [1] [2]

Discoidin domain receptor family, member 2, also known as DDR2 or CD167b (cluster of differentiation 167b), is a human gene.[1]

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.[1]

Interactions

DDR2 (gene) has been shown to interact with SHC1.[2]

References

  1. ^ a b "Entrez Gene: DDR2 discoidin domain receptor family, member 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4921. 
  2. ^ Ikeda, Kazuo; Wang Li-Hsien, Torres Richard, Zhao Hong, Olaso Elvira, Eng Francis J, Labrador Pablo, Klein Rudiger, Lovett David, Yancopoulos George D, Friedman Scott L, Lin Hsin Chieh (May. 2002). "Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen". J. Biol. Chem. (United States) 277 (21): 19206–12. doi:10.1074/jbc.M201078200. ISSN 0021-9258. PMID 11884411. 

Further reading

EPH receptor family
EPHA1 · EPHA2 · EPHA3 · EPHA4 · EPHA5 · EPHA6 · EPHA7 · EPHA8 · EPHB1 · EPHB2 · EPHB3 · EPHB4 · EPHB5 · EPHB6 · EPHX
LTK receptor family
LTK · ALK
TIE · TEK
ROR receptor family
ROR1 · ROR2
DDR1 · DDR2
AATYK · AATYK2 · AATYK3
AXL · MER · TYRO3
uncatagorised
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

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