dTDP-4-amino-4,6-dideoxy-D-glucose transaminase

dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
Identifiers
EC number 2.6.1.33
CAS number 9023-19-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a dTDP-4-amino-4,6-dideoxy-D-glucose transaminase (EC 2.6.1.33) is an enzyme that catalyzes the chemical reaction

dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate \rightleftharpoons dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate

Thus, the two substrates of this enzyme are dTDP-4-amino-4,6-dideoxy-D-glucose and 2-oxoglutarate, whereas its two products are dTDP-4-dehydro-6-deoxy-D-glucose and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase. Other names in common use include thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase, thymidine diphospho-4-amino-6-deoxyglucose aminotransferase, thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase, thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase, and TDP-4-keto-6-deoxy-D-glucose transaminase. This enzyme participates in nucleotide sugars metabolism. It employs one cofactor, pyridoxal phosphate.

References

  • Matsuhashi M, Strominger JL (1966). "Thymidine diphosphate 4-acetamido-2,6-dideoxyhexoses. 3 Purification and properties of thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase from Escherichia coli strain B". J. Biol. Chem. 241 (20): 4738–44. PMID 5332731. 
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