dTDP-4-amino-4,6-dideoxygalactose transaminase

dTDP-4-amino-4,6-dideoxygalactose transaminase
dTDP-4-amino-4,6-dideoxygalactose transaminase
Identifiers
EC number 2.6.1.59
CAS number 72560-97-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a dTDP-4-amino-4,6-dideoxygalactose transaminase (EC 2.6.1.59) is an enzyme that catalyzes the chemical reaction

dTDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate \rightleftharpoons dTDP-4-dehydro-6-deoxy-D-galactose + L-glutamate

Thus, the two substrates of this enzyme are dTDP-4-amino-4,6-dideoxy-D-galactose and 2-oxoglutarate, whereas its two products are dTDP-4-dehydro-6-deoxy-D-galactose and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is dTDP-4,6-dideoxy-D-galactose:2-oxoglutarate aminotransferase. Other names in common use include thymidine diphosphoaminodideoxygalactose aminotransferase, and thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase. It employs one cofactor, pyridoxal phosphate.

References

  • Oashi H, Matsuhashi M, Matsuhashi S (1971). "Thymidine diphosphate 4-acetamido-4,6-dideoxyhexoses. IV Purification and properties of thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase from Pasteurella pseudotuberculosis". J. Biol. Chem. 246 (8): 2325–30. PMID 4928644. 
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