DTNB

DTNB
Dystrobrevin, beta
Identifiers
Symbols DTNB; MGC17163; MGC57126
External IDs OMIM602415 MGI1203728 HomoloGene74875 GeneCards: DTNB Gene
Orthologs
Species Human Mouse
Entrez 1838 13528
Ensembl ENSG00000138101 ENSMUSG00000071454
UniProt O60941 O70585
RefSeq (mRNA) NM_021907.3 NM_001162465
RefSeq (protein) NP_068707.1 NP_001155937
Location (UCSC) Chr 2:
25.6 – 25.9 Mb
Chr 12:
3.57 – 3.78 Mb
PubMed search [1] [2]

Beta dystrobrevin also known as DTNB is a protein which in humans is encoded by the DTNB gene.[1]

Function

This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • DTNB — 5,5´ dithiobis (2 nitrobenzoic) acid …   Medical dictionary

  • DTNB — • 5,5´ dithiobis (2 nitrobenzoic) acid …   Dictionary of medical acronyms & abbreviations

  • Brighton Mall — Infobox shopping mall shopping mall name = Brighton Mall image width = 180px caption = Brighton Mall location = Brighton, Michigan, United States coordinates = opening date = 1970 closing date = developer = manager = Landmark Commercial owner =… …   Wikipedia

  • Obi Ezeh — Ezeh attempts to shoestring tackle Beanie Wells during the 2008 Michigan – Ohio State rivalry game. No.    &# …   Wikipedia

  • Michigan Association of Broadcasters — Abbreviation MAB Purpose/focus Broadcasting Headquarters Lansing, Michigan Region served Michigan Official …   Wikipedia

  • Ellman's reagent — Ellman s reagent[1] IUPAC name 5 (3 Carboxy 4 nitrophenyl)disulfany …   Wikipedia

  • Summit Place Mall — Infobox shopping mall shopping mall name = Summit Place Mall image width = caption = location = Waterford Township, Michigan, United States opening date = 1963 developer = manager = Namco Corporation number of stores = approx. 60, originally… …   Wikipedia

  • Diversified industrial staffing — Infobox Company company name = Diversified Industrial Staffing company type = Private foundation = 1997 key people = Todd Palmer: Founder and CEO location city = Troy, Michigan industry = Human Resources, Recruitment, Staffing website =… …   Wikipedia

  • Denard Robinson — Robinson takes the long snap for the 2010 Michigan …   Wikipedia

  • Jerry Green (writer) — Jerry Green is an American sports journalist and author. He was a staff writer for the Associated Press from 1956 to 1963 and for The Detroit News from 1963 to 2004. He was inducted into the Pro Football Hall of Fame in 2005 and the Michigan… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”