- Proxymetacaine
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Proxymetacaine Systematic (IUPAC) name 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate Clinical data AHFS/Drugs.com International Drug Names Pregnancy cat. C(US) Legal status ? Routes Topical (eye drops) Pharmacokinetic data Metabolism Plasma Identifiers CAS number 499-67-2
5875-06-9 (HCl)ATC code S01HA04 PubChem CID 4935 DrugBank APRD00522 ChemSpider 4766 UNII B4OB0JHI1X KEGG D08448 ChEMBL CHEMBL1196 Chemical data Formula C16H26N2O3 Mol. mass 294.389 g/mol SMILES eMolecules & PubChem (what is this?) (verify) Proxymetacaine (INN) or proparacaine (USAN) is a topical anesthetic drug of the aminoester group.
Contents
Clinical pharmacology
Indications and usage
Proxymetacaine hydrochloride ophthalmic solution (eye drops) is indicated for procedures such as tonometry, gonioscopy, removal of foreign bodies, or other similar procedures requiring topical anesthesia of the cornea and conjunctiva.
Warnings
Proxymetacaine is for topical ophthalmic use only, and it is specifically not intended for injection. Prolonged use of this or any other topical ocular anesthetic may produce permanent corneal opacification with accompanying visual loss.
Mechanism of action
Proxymetacaine is believed to act as an antagonist on voltage-gated sodium channels to affect the permeability of neuronal membranes; how this inhibits pain sensations and the exact mechanism of action of proxymetacaine are, however, unknown.
How supplied
Proxymetacaine is available as its hydrochloride salt in ophthalmic solutions at a concentration of 0.5%. Although it is no longer on patent, it is still marketed under the trade names Alcaine, Ak-Taine, and others.
Anesthetics: Local anesthetics - primarily sodium channel blockers (N01B) Esters Esters of aminobenzoic acidAmylocaine • Benzocaine • Butacaine • Butamben • Chloroprocaine • Dimethocaine • Meprylcaine • Metabutoxycaine • Orthocaine • Propoxycaine • Procaine (Novocaine) • Proxymetacaine • Risocaine • TetracaineEsters of benzoic acidAmides Articaine • Bupivacaine # /Levobupivacaine/Ropivacaine • Carticaine • Cinchocaine • Etidocaine • Lidocaine # • Mepivacaine • Prilocaine • TrimecaineCombinations This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.