Domain of unknown function

Domain of unknown function

A Domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. There are now over 3,000 DUF families within the Pfam database representing over 20% of known families.[1]

Contents

History

The DUF naming scheme was introduced by Chris Ponting, through the addition of DUF1 and DUF2 to the SMART database.[2] These two domains were found to be widely distributed in bacterial signaling proteins. Subsequently, the functions of these domains were identified and they have since been renamed as the GGDEF domain and EAL domain respectively.

Structure

Structural genomics programmes have attempted to understand the function of DUFs through structure determination. The structures of over 250 DUF families have been solved.[3] This work showed that about two thirds of DUF families had a structure similar to a previously solved one and therefore likely to be divergent members of existing protein superfamilies, whereas about one third possessed a novel protein fold.

External links

References

  1. ^ Bateman A, Coggill P, Finn RD (October 2010). "DUFs: families in search of function". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (Pt 10): 1148–52. doi:10.1107/S1744309110001685. PMC 2954198. PMID 20944204. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2954198. 
  2. ^ Schultz J, Milpetz F, Bork P, Ponting CP (May 1998). "SMART, a simple modular architecture research tool: identification of signaling domains". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 5857–64. doi:10.1073/pnas.95.11.5857. PMC 34487. PMID 9600884. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=34487. 
  3. ^ Jaroszewski L, Li Z, Krishna SS, et al. (September 2009). "Exploration of uncharted regions of the protein universe". PLoS Biol. 7 (9): e1000205. doi:10.1371/journal.pbio.1000205. PMC 2744874. PMID 19787035. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2744874. 

Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • Domain of a function — Venn diagram showing f, a function from domain X to codomain Y. The smaller oval inside Y is the image of f, sometimes called the range of f. In mathematics, the domain of definition or simply the domain of a function is the set of input or… …   Wikipedia

  • Domain Name System — The Domain Name System (DNS) is a hierarchical distributed naming system for computers, services, or any resource connected to the Internet or a private network. It associates various information with domain names assigned to each of the… …   Wikipedia

  • Domain (mathematics) — In mathematics, the domain of a given functionis the set of input values for which the function is defined. [Paley, H. Abstract Algebra , Holt, Rinehart and Winston, 1966 (p. 16).] For instance, the domain of cosine would be all real numbers,… …   Wikipedia

  • Function approximation — The need for function approximations arises in many branches of applied mathematics, and computer science in particular. In general, a function approximation problem asks us to select a function among a well defined class that closely matches (… …   Wikipedia

  • Convex function — on an interval. A function (in black) is convex if and only i …   Wikipedia

  • CARD domain — Caspase recruitment domains, or CARD domains, are interaction motifs found in a wide array of proteins, typically those involved in processes relating to inflammation and apoptosis. These domains mediate the formation of larger protein complexes… …   Wikipedia

  • Data domain — For other uses, see Data domain (disambiguation). In data management and database analysis, a data domain refers to all the unique values which a data element may contain. The rule for determining the domain boundary may be as simple as a data… …   Wikipedia

  • DUF1220 — Domain of unknown function (DUF1220) Identifiers Symbol DUF1220 Pfam PF06758 InterPro …   Wikipedia

  • C11orf73 — chromosome 11 open reading frame 73 [[file:‎|border|250px|alt=]] A Phyre homology model of the human C11orf73 protein.[1] Identifiers Symbols …   Wikipedia

  • C11orf1 — Chromosome 11 open reading frame 1 Identifiers Symbols C11orf1; FLJ23499 External IDs …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”