Drug Industry Document Archive

The Drug Industry Document Archive (DIDA) is a digital archive of pharmaceutical industry documents created and maintained by the University of California, San Francisco, Library and Center for Knowledge Management. DIDA contains documents about pharmaceutical industry clinical trials, publication of study results, pricing, marketing, relations with physicians and drug company involvement in continuing medical education.

Most of the previously secret documents on DIDA were made public as a result of lawsuits against the following pharmaceutical companies: Merck & Co., Parke-Davis, Warner-Lambert, Pfizer, Wyeth and Abbott Labs.

Researchers as well as students, journalists, and the general public, use the archive to investigate the ways pharmaceutical companies market their products. The UCSF Library created this digital archive in an attempt to facilitate further research into the drug industry's practice of establishing close links with the medical community which has been shown to influence scientific research, drug approval, prescription practices, and ultimately, consumer health.^{[1] [2]}

Collections

DIDA contains:

• internal pharmaceutical company documents
• correspondence between drug companies and physicians, researchers and educational institutions
• regulatory and legal documents
• court filings
• depositions
• expert reports
• internal University documents

Documents in DIDA come from a variety of sources including:

• Lawsuits against Merck & Co. regarding the marketing and use of Vioxx
• The landmark whistleblower case involving Neurontin (gabapentin) and off-label marketing: United States of America ex rel. David Franklin vs. Parke-Davis, Division of Warner-Lambert/Pfizer
• Investigations into conflict of interest and academic institutions by the US Senate Finance Committee, headed by Charles Grassley (R-Iowa)
• Investigations into the marketing of Vioxx to physicians by the United States House Committee on Oversight and Government Reform, headed by Henry A. Waxman
• Anti-trust litigation involving Abbott Labs and their HIV/AIDS drug Norvir
• Lawsuits against Wyeth for the unethical promotion of the hormone replacement drug Premarin to women. Wyeth paid medical ghostwriters to author journal articles about the drug.

References

1. ^ Steinman MA, Bero LA, Chren MM, Landefeld CS. Narrative review: The promotion of gabapentin: An analysis of internal industry documents. Ann Intern Med. 2006 Aug 15;145(4):284-93. Available at: http://www.annals.org/cgi/content/full/145/4/284.
2. ^ Ross J, et al. Guest Authorship and Ghostwriting in Publications Related to Rofecoxib: A case study of industry documents from Rofecoxib Litigation. JAMA. 2008;299(15):1800-1812. Available at: http://dx.doi.org/10.1001/jama.299.15.1800

Further reading

• Hill K., et al. The ADVANTAGE Seeding Trial: A Review of Internal Documents. Annals of Internal Medicine 2008 Aug. 149(4):251-258.
• Landefeld, S and Steinman, M. The Neurontin Legacy - Marketing through Misinformation. NEJM Jan 8;360(2):103-6.
• Waxman, HA. Memorandum to the Democratic Members of the Government Reform Committee: The marketing of Vioxx to physicians. May 5, 2005. Committee on Government Reform Minority Office, United States House of Representatives.

External links

• Official website
• The Prescription Project. Accessed 1/7/2009.
• The Prescription Access Litigation Project (PAL). Accessed 1/7/2009.
• SourceWatch articles on the Pharmaceutical Industry. Accessed 1/7/2009.
• No Free Lunch. Accessed 1/7/2009.
• Healthy Skepticism. Accessed 1/7/2009.