Marinobufagenin

Marinobufagenin
Other names Marinobufagin, Marinobufagenin
Identifiers
CAS number	470-42-8
PubChem	10104
Jmol-3D images	Image 1
SMILES C[C@]12CC[C@@H](C[C@]1(CCC3C2CC[C@]4([C@]35[C@H](O5)C[C@@H]4C6=COC(=O)C=C6)C)O)O
Properties
Molecular formula	C24H32O5
Molar mass	400.51 g mol−1
Hazards
Main hazards	Toxic
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Marinobufagin is a cardiotonic bufadienolide steroid secreted by the toad Bufo rubescens^[1] and other related species such as Bufo marinus. It is a vasoconstrictor with effects similar to digitalis.^[2]

References

1. ^ Cunha Filho GA, Schwartz CA, Resck IS, Murta MM, Lemos SS, Castro MS, Kyaw C, Pires OR Jr, Leite JR, Bloch C Jr, Schwartz EF. Antimicrobial activity of the bufadienolides marinobufagin and telocinobufagin isolated as major components from skin secretion of the toad Bufo rubescens. Toxicon. 2005 May;45(6):777-82. PMID 15804527
2. ^ Fedorova OV, Talan MI, Agalakova NI, Lakatta EG, Bagrov AY. Endogenous ligand of alpha(1) sodium pump, marinobufagenin, is a novel mediator of sodium chloride--dependent hypertension. Circulation. 2002 Mar 5;105(9):1122-7. PMID 11877366