- Viral matrix protein
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Viral matrix protein Identifiers Symbol Matrix Pfam PF00661 InterPro IPR000982 Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary Viral matrix proteins are non structural proteins linking the viral envelope with the virus core. They play a crucial role in virus assembly, and interact with the RNP complex as well as with the viral membrane. It is found in Morbillivirus, Paramyxovirus, Orthomyxovirus and Pneumovirus.
An example is the M1 protein of the influenza virus, showing affinity to the glycoproteins of the host cell membrane on one side of its molecule and nonspecific affinity for the RNA molecules on its other end, which allows it to form a layer under the membrane, to which the assembled complexes of viral ribonucleoprotein and viral RNA bind and are enveloped and bud out of the cell as new mature viruses.
Viral matrix proteins are responsible for expelling the genetic material once a virus has entered a cell.
DNA RNA capsid: matrix protein (M1 protein) · viral envelope (M2 protein)
glycoprotein: Influenza hemagglutinin · NeuraminidaseParainfluenzaParainfluenza hemagglutinin-neuraminidaseRSVRespiratory syncytial virus G proteinRT VSPs: gag · pol (Integrase, Reverse transcriptase, HIV-1 protease) · env (gp120, gp41)
VRAPs: transactivators (Tat, Rev, Vpr) · Nef · Vif · VpuFusion protein Categories:- Virology
- Viral structural proteins
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