Methimepip

Methimepip: Methimepip

IUPAC name

4-(1H-imidazol-4-ylmethyl)-1-methylpiperidine

Identifiers

CAS number 151070-80-3^Y

PubChem 11313837

ChEMBL CHEMBL175782^N

IUPHAR ligand 1254

Jmol-3D images Image 1

SMILES

CN1CCC(CC1)CC2=CN=CN2

Properties

Molecular formula C₁₀H₁₇N₃

Molar mass 179.262 g/mol

N (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)

Infobox references

Methimepip is a histamine agonist which is highly selective for the H₃ subtype. It is the N-methyl derivative of immepip.^[1]

References

^ Kitbunnadaj R, Hashimoto T, Poli E, et al. (March 2005). "N-substituted piperidinyl alkyl imidazoles: discovery of methimepip as a potent and selective histamine H3 receptor agonist". Journal of Medicinal Chemistry 48 (6): 2100–7. doi:10.1021/jm049475h. PMID 15771452.

v · d · eHistaminergics

Receptor
ligands

H₁

Agonists: 2-Pyridylethylamine • Betahistine • Histamine • HTMT • UR-AK49
Antagonists: 1st generation: 4-Methyldiphenhydramine • Alimemazine • Antazoline • Azatadine • Bamipine • Benzatropine (Benztropine) • Bepotastine • Bromazine • Brompheniramine • Buclizine • Captodiame • Carbinoxamine • Chlorcyclizine • Chloropyramine • Chlorothen • Chlorphenamine • Chlorphenoxamine • Cinnarizine • Clemastine • Clobenzepam • Clocinizine • Cyclizine • Cyproheptadine • Dacemazine • Deptropine • Dexbrompheniramine • Dexchlorpheniramine • Dimenhydrinate • Dimetindene • Diphenhydramine • Diphenylpyraline • Doxylamine • Embramine • Etybenzatropine (Ethylbenztropine) • Etymemazine • Histapyrrodine • Homochlorcyclizine • Hydroxyethylpromethazine • Hydroxyzine • Isopromethazine • Isothipendyl • Meclozine • Mepyramine (Pyrilamine) • Mequitazine • Methafurylene • Methapyrilene • Methdilazine • Moxastine • Niaprazine • Orphenadrine • Oxatomide • Oxomemazine • Phenindamine • Pheniramine • Phenyltoloxamine • Pimethixene • Piperoxan • Promethazine • Propiomazine • Pyrrobutamine • Talastine • Thenalidine • Thenyldiamine • Thiazinamium • Thonzylamine • Tolpropamine • Tripelennamine • Triprolidine; 2nd generation: Acrivastine • Astemizole • Azelastine • Cetirizine • Clemizole • Clobenztropine • Ebastine • Emedastine • Epinastine • Ketotifen • Latrepirdine • Levocabastine • Loratadine • Mebhydrolin • Mizolastine • Olopatadine • Rupatadine • Setastine • Terfenadine; "3rd generation": Desloratadine • Fexofenadine • Levocetirizine; Miscellaneous: Tricyclic antidepressants (Amitriptyline, Doxepin, Trimipramine, etc) • Tetracyclic antidepressants (Mianserin, Mirtazapine, etc) • Serotonin antagonist and reuptake inhibitors (Trazodone, Nefazodone) • Typical antipsychotics (Chlorpromazine, Thioridazine, etc) • Atypical antipsychotics (Clozapine, Olanzapine, Quetiapine, etc)

H₂

Agonists: Amthamine • Betazole • Dimaprit • Histamine • HTMT • Impromidine • UR-AK49
Antagonists: Burimamide • Cimetidine • Ebrotidine • Famotidine • Lafutidine • Lavoltidine/Loxtidine • Lupitidine • Metiamide • Niperotidine • Nizatidine • Oxmetidine • Ranitidine • Roxatidine

H₃

Agonists: α-Methylhistamine • Cipralisant • Histamine • Imetit • Immepip • Immethridine • Methimepip • Proxyfan
Antagonists: A-349,821 • A-423,579 • ABT-239 • Betahistine • Burimamide • Ciproxifan • Clobenpropit • Conessine • GSK-189,254 • Impentamine • Iodophenpropit • JNJ-5,207,852 • MK-0249 • NNC-38-1,049 • PF-03654746 • Pitolisant • SCH-79,687 • Thioperamide • VUF-5,681

H₄

Agonists: 4-Methylhistamine • Histamine • VUF-8,430
Antagonists: JNJ-7,777,120 • Thioperamide • VUF-6,002

Reuptake
inhibitors

Vesicular

VMAT inhibitors

Ibogaine • Reserpine • Tetrabenazine

Enzyme
inhibitors

Anabolism

HDC inhibitors

Catechin • Meciadanol • Naringenin • Tritoqualine

Catabolism

HNMT inhibitors

Amodiaquine • Diphenhydramine • Harmaline • Quinacrine • Tacrine

DAO inhibitors

Aminoguanidine

Others

Precursors

L-Histidine

Cofactors

Vitamin B6 (pyridoxine, pyridoxamine, pyridoxal → Pyridoxal phosphate)

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.

Academic Dictionaries and Encyclopedias

Methimepip

References

Look at other dictionaries:

Share the article and excerpts

Methimepip

IUPAC name 4-(1H-imidazol-4-ylmethyl)-1-methylpiperidine
Identifiers
CAS number	151070-80-3^Y
PubChem	11313837
ChEMBL	CHEMBL175782^N
IUPHAR ligand	1254
Jmol-3D images	Image 1
SMILES CN1CCC(CC1)CC2=CN=CN2
Properties
Molecular formula	C₁₀H₁₇N₃
Molar mass	179.262 g/mol
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Academic Dictionaries and Encyclopedias

Wikipedia

Methimepip

References

Look at other dictionaries:

Share the article and excerpts

Direct link