mir-24 microRNA precursor family

mir-24 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-24
Identifiers
Symbol	mir-24
Rfam	RF00178
miRBase	MI0000080
miRBase family	MIPF0000041
Other data
RNA type	Gene; miRNA
Domain(s)	Eukaryota
GO	0035195 0035068
SO	0001244

The miR-24 microRNA precursor is a small non-coding RNA molecule that regulates gene expression. microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a mature ~22 nucleotide product. In this case the mature sequence comes from the 3' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA. miR-24 has been identified in human and mouse.^[1][2]

Targets of miR-24

• Lal et al. suggested that miR-24 suppresses the tumor suppressor p16(INK4a).^[3]
• Wang et al.. have shown that miR-24 reduces the mRNA and protein levels of human ALK4 by targeting the 3'-untranslated region of mRNA.^[4]
• Mishra et al. suggest that miR-24 targets the DHFR gene.^[5]

References

1. ^ Lagos-Quintana, M; Rauhut R, Lendeckel W, Tuschl T (2001). "Identification of novel genes coding for small expressed RNAs". Science 294 (5543): 853–858. doi:10.1126/science.1064921. PMID 11679670. 
2. ^ Ambros, V (2001). "microRNAs: tiny regulators with great potential". Cell 107 (7): 823–826. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458. 
3. ^ Lal A, Kim HH, Abdelmohsen K, et al (2008). Preiss, Thomas. ed. "p16(INK4a) translation suppressed by miR-24". PLoS ONE 3 (3): e1864. doi:10.1371/journal.pone.0001864. PMC 2274865. PMID 18365017. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2274865. 
4. ^ Wang Q, Huang Z, Xue H, et al (January 2008). "MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4". Blood 111 (2): 588–95. doi:10.1182/blood-2007-05-092718. PMID 17906079. 
5. ^ Mishra PJ, Humeniuk R, Mishra PJ, Longo-Sorbello GS, Banerjee D, Bertino JR (August 2007). "A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance". Proceedings of the National Academy of Sciences of the United States of America 104 (33): 13513–8. doi:10.1073/pnas.0706217104. PMC 1948927. PMID 17686970. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1948927. 

External links

• Rfam page for mir-24 microRNA precursor family
• miRBase family MIPF0000041