6-Monoacetylcodeine

6-Monoacetylcodeine

Systematic (IUPAC) name
3-methoxy-6-acetyl-(5α,6α)-7,8-didehydro-4,5-epoxy-
Clinical data
Pregnancy cat.	?
Legal status	?
Routes	Intravenous (if present in heroin)
Identifiers
CAS number	6703-27-1 Y
ATC code	None
PubChem	CID 5745725
ChemSpider	4588962 Y
Synonyms	6-acetylcodeine
Chemical data
Formula	C20H23NO4
Mol. mass	341.4 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C20H23NO4/c1-11(22)24-16-7-5-13-14-10-12-4-6-15(23-3)18-17(12)20(13,19(16)25-18)8-9-21(14)2/h4-7,13-14,16,19H,8-10H2,1-3H3/t13-,14+,16-,19-,20-/m0/s1 Y Key:MFXFQKMUCYHPFQ-BKRJIHRRSA-N Y
Y(what is this?)  (verify)

6-Monoacetylcodeine (6-MAC) is a toxic acetate ester of codeine in which the hydroxyl group on the 6 position has been acetylated. It is occasionally present as an impurity in street heroin and is typically created when attempting to create heroin from a solution of morphine in which some of the codeine from the original opium solution still remains. It is formed either through the addition of acetic anhydride, which will only acetylate the 6 position on the codeine or as a result of the addition of acetic acid with a catalyst in an attempt to create 6-monoacetylmorphine, the equivalent ester of morphine which is slightly more potent than heroin itself. Administration of 6-MAC through any route results in the rapid release of histamine into the blood stream which can lead to potentially fatal anaphylactic shock. 6-monoacetylcodeine is eventually metabolised into codeine and then into morphine. Since only illegally produced heroin is likely to contain 6-MAC, testing for the presence of it in the urine can be used as a fairly reliable method of detecting the use of illicit heroin, as opposed to prescription painkillers. ^[1]

See also

• 6-Monoacetylmorphine, the equivalent form of morphine
• Codeine
• Poppy tea

References

1. ^ * Detection of Acetylcodeine in Urine

External links

• Acetylcodeine, an impurity of illicitly manufactured heroin Pubmed

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