Negative allosteric modulator

A negative allosteric modulator (NAM) is a drug which decreases the activity of a receptor indirectly via disactivation of an allosteric site on the protein. NAMs are similar to inverse agonists in that they conteract overall receptor activation, but they are different because they do so in a functionally distinctive way.

Main article: Allosteric regulation

See also

• Positive allosteric modulator

References

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