Nifuratel

Nifuratel
Nifuratel
Systematic (IUPAC) name
5-[(methylthio)methyl]-3-{[(1E)-(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 4936-47-4
ATC code G01AX05
PubChem CID 6433427
UNII U60U6P08SP YesY
KEGG D01050 YesY
Chemical data
Formula C10H11N3O5S 
Mol. mass 285.28 g/mol
 YesY(what is this?)  (verify)

Nifuratel is a drug used in gynecology. It is a local antiprotozoal and antifungal agent that may also be given orally.

Nifuratel appears to have a broad antibacterial spectrum of action and is effective against Chlamydia trachomatis and Mycoplasma spp. as well as fungal infections from Candida spp.[1]

Taken orally, or as a vaginal pessary, it is used in the treatment of a wide range of infections of the genito-urinary tract, especially if there is no accurate diagnosis available. For example it may be used in the treatment of women exhibiting vaginal discharge where there is uncertainty as to whether the cause is Trichomonas vaginalis or Candida strains such as Candida albicans.

Side effects appear to be minimal or non-existent and it has a safe toxicological profile.[2]

References

  1. ^ Treatment of candidal urinary tract infection with nifuratel. R N Grüneberg, A Leakey
  2. ^ Microbiological and pharmaco-toxicological profile of nifuratel and its favourable risk/benefit ratio for the treatment of vulvo-vaginal infections. A review. Werner Mendling, Federico Mailland Klinik für Frauenheilkunde und Geburtshilfe, Klinikum Am Urban, Berlin, Germany.

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