Enprofylline

Enprofylline: Enprofylline

Systematic (IUPAC) name

3-propyl-7H-purine-2,6-dione

Clinical data

Pregnancy cat. ?

Legal status ?

Identifiers

CAS number 41078-02-8^Y

ATC code ?

PubChem CID 1676

DrugBank DB00824

ChemSpider 1613^Y

UNII DT7DT5E518^N

ChEBI CHEBI:126237^N

ChEMBL CHEMBL279898^N

Chemical data

Formula C₈H₁₀N₄O₂

Mol. mass 194.190 g/mol

SMILES eMolecules & PubChem

InChI

InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14)^Y
Key:SIQPXVQCUCHWDI-UHFFFAOYSA-N^Y

N(what is this?) (verify)

Enprofylline (3-Propylxanthine) is a xanthine derivative used in the treatment of asthma, which acts as a bronchodilator. It acts primarily as a competitive nonselective phosphodiesterase inhibitor with relatively little activity as a nonselective adenosine receptor antagonist.^[1]^[2]

References

^ Lunell E, Svedmyr N, Andersson KE, Persson CG (1982). "Effects of enprofylline, a xanthine lacking adenosine receptor antagonism, in patients with chronic obstructive lung disease". European Journal of Clinical Pharmacology 22 (5): 395–402. PMID 6288396.

^ Laursen LC (December 1987). "Anti asthmatic effects and pharmacokinetics of enprofylline--a new xanthine derivate". Danish Medical Bulletin 34 (6): 289–97. PMID 3325233.

v · d · eDrugs for obstructive airway diseases: asthma/COPD (R03)

Adrenergics, inhalants

Short acting β₂-agonists

Salbutamol^#/Levosalbutamol • Fenoterol • Terbutaline • Pirbuterol • Procaterol • Bitolterol • Rimiterol • Carbuterol • Tulobuterol • Reproterol

Long acting β₂-agonists (LABA)

Arformoterol • Bambuterol • Clenbuterol • Formoterol • Salmeterol Ultra LABA: Indacaterol

other

Epinephrine^# • Hexoprenaline • Isoprenaline (Isoproterenol) • Orciprenaline (Metaproterenol)

Glucocorticoids
Beclometasone^# • Budesonide • Ciclesonide • Fluticasone • Mometasone • Flunisolide • Betamethasone • Triamcinolone

Anticholinergics/
muscarinic antagonist
Ipratropium bromide^# • Oxitropium bromide • Tiotropium bromide

Mast cell stabilizers
Cromoglicate • Nedocromil

Xanthines
Doxofylline • Enprofylline • Theobromine • Theophylline/Aminophylline/Choline theophyllinate

Eicosanoid inhibition

Leukotriene antagonists

Montelukast • Pranlukast • Zafirlukast

Lipoxygenase inhibitor

Zileuton

Thromboxane receptor antagonists

Ramatroban • Seratrodast

Combination products
Budesonide/formoterol • Fluticasone/salmeterol • Ipratropium bromide/salbutamol • Mometasone/formoterol

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: RES

anat(n, x, l, c)/phys/devp

noco(c, p)/cong/tumr, sysi/epon, injr

proc, drug(R1/2/3/5/6/7)

v · d · eAdenosinergics

Receptor ligands

Agonists

2-(1-Hexynyl)-N-methyladenosine • 2-Cl-IB-MECA • 2'-MeCCPA • 5'-N-ethylcarboxamidoadenosine • ATL-146e • BAY 60–6583 • CCPA • CGS-21680 • CP-532,903 • GR 79236 • LUF-5835 • LUF-5845 • N6-Cyclopentyladenosine • Regadenoson • SDZ WAG 994 • UK-432,097

Antagonists

8-Phenyl-1,3-dipropylxanthine • Acefylline • Aminophylline • Bamifylline • Caffeine • CGS-15943 • 8-Chlorotheophylline • CPX • CVT-6883 • Dimethazan • DPCPX • Fenethylline • Istradefylline • KF-26777 • MRE3008F20 • MRS-1220 • MRS-1334 • MRS-1706 • MRS-1754 • MRS-3777 • Paraxanthine • Pentoxifylline • Preladenant • Propentofylline • PSB-10 • PSB-11 • PSB 36 • PSB-603 • PSB-788 • PSB-1115 • Rolofylline • SCH-442,416 • SCH-58261 • Theobromine • Theophylline • VUF-5574 • ZM-241,385

Reuptake inhibitors

Plasmalemmal

ENT inhibitors

Dilazep • Dipyridamole • Hexobendine • Pentoxifylline • Propentofylline

Vesicular

VNT inhibitors

Categories:
Adenosine antagonists
Bronchodilators
Xanthines
Phosphodiesterase inhibitors

Enprofylline

Systematic (IUPAC) name
3-propyl-7H-purine-2,6-dione
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	41078-02-8^Y
ATC code	?
PubChem	CID 1676
DrugBank	DB00824
ChemSpider	1613^Y
UNII	DT7DT5E518^N
ChEBI	CHEBI:126237^N
ChEMBL	CHEMBL279898^N
Chemical data
Formula	C₈H₁₀N₄O₂
Mol. mass	194.190 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14)^Y Key:SIQPXVQCUCHWDI-UHFFFAOYSA-N^Y
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Enprofylline

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