Nucleoside-triphosphate—adenylate kinase

nucleoside triphosphate adenylate kinase
Identifiers
EC number	2.7.4.10
CAS number	9026-74-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a nucleoside-triphosphate-adenylate kinase (EC 2.7.4.10) is an enzyme that catalyzes the chemical reaction

nucleoside triphosphate + AMP $\rightleftharpoons$ nucleoside diphosphate + ADP

Thus, the two substrates of this enzyme are nucleoside triphosphate and AMP, whereas its two products are nucleoside diphosphate and ADP.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is nucleoside-triphosphate:AMP phosphotransferase. Other names in common use include guanosine triphosphate-adenylate kinase, nucleoside triphosphate-adenosine monophosphate transphosphorylase, GTP:AMP phosphotransferase, and isozyme 3 of adenylate kinase. This enzyme participates in pyrimidine metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1ZD8 and 2AK3.

References

• Albrecht GJ (1970). "Purification and properties of nucleoside triphosphate-adenosine monophosphate transphosphorylase from beef heart mitochondria". Biochemistry. 9 (12): 2462–70. doi:10.1021/bi00814a011. PMID 5423264. 
• CHIGA M, ROGERS AE, PLAUT GW (1961). "Nucleotide transphosphorylases from liver. II. Purification and properties of a 6-oxypurine nucleoside triphosphate-adenosine monophosphate transphosphorylase from swine liver". J. Biol. Chem. 236: 1800–5. PMID 13693071. 

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