- Omigapil
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Omigapil 
Systematic (IUPAC) name Dibenzo[b,f]oxepin-10-ylmethyl-methyl-prop-2-ynylamine Clinical data Pregnancy cat. ? Legal status Investigational Identifiers CAS number 181296-84-4 ATC code None PubChem CID 6419718 UNII 5V14HD0N4Q Chemical data Formula C19H17NO Mol. mass 275.13 g/mol SMILES eMolecules & PubChem - InChI=1S/C19H17NO/c1-3-12-20(2)14-16-13-15-8-4-6-10-18(15)21-19-11-7-5-9-17(16)19/h1,4-11,13H,12,14H2,2H3
Key:QLMMOGWZCFQAPU-UHFFFAOYSA-N
Omigapil (TCH346) is a drug that was developed by Novartis and tested in clinical trials for its ability to help treat Parkinson's disease[1] and amyotrophic lateral sclerosis (ALS).[2] The development for ALS has been terminated due to lack of benefit, but Santhera Pharmaceuticals bought the compound for development for the treatment of congenital muscular dystrophy.[3][4]
References
- ^ Olanow, C. W.; Schapira, A. H.; Lewitt, P. A.; Kieburtz, K.; Sauer, D.; Olivieri, G.; Pohlmann, H.; Hubble, J. (2006). "TCH346 as a neuroprotective drug in Parkinson's disease: A double-blind, randomised, controlled trial". The Lancet Neurology 5 (12): 1013. doi:10.1016/S1474-4422(06)70602-0.
- ^ ClinicalTrials.gov NCT00036413 A 12-Week, Multicenter, Safety and Dose-Ranging Study of 3 Oral Doses of TCH346 in Patients With Amyotrophic Lateral Sclerosis
- ^ Santhera to Test Compound in CMD
- ^ Meinen, S.; Lin, S.; Thurnherr, R.; Erb, M.; Meier, T.; Rüegg, M. A. (2011). "Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice". EMBO Molecular Medicine 3 (8): 465–479. doi:10.1002/emmm.201100151. PMID 21674808.
- Andringa, G.; Eshuis, S.; Perentes, E.; Maguire, R. P.; Roth, D.; Ibrahim, M.; Leenders, K. L.; Cools, A. R. (2003). "TCH346 prevents motor symptoms and loss of striatal FDOPA uptake in bilaterally MPTP-treated primates". Neurobiology of disease 14 (2): 205–217. PMID 14572443.
- Hara, M. R.; Thomas, B.; Cascio, M. B.; Bae, B. I.; Hester, L. D.; Dawson, V. L.; Dawson, T. M.; Sawa, A. et al. (2006). "Neuroprotection by pharmacologic blockade of the GAPDH death cascade". Proceedings of the National Academy of Sciences 103 (10): 3887–3889. doi:10.1073/pnas.0511321103. PMC 1450161. PMID 16505364. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1450161.
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