Oxantel

Oxantel
Oxantel
Systematic (IUPAC) name
3-[(E)-2-(1-Methyl-5,6-dihydro-4H-pyrimidin-2-yl)ethenyl]phenol
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 68813-55-8
ATC code P02CC02 QP52AF03
PubChem CID 5281087
UNII 94AJJ30D9E YesY
KEGG D00806 YesY
Chemical data
Formula C13H16N2O 
Mol. mass 216.28 g/mol
 YesY(what is this?)  (verify)

Oxantel is an anthelmintic. It has typically been used human and animal use as a standard treatment for intestinal worms.

Oxantel is currently[when?] being experimented with for the treatment of periodontal disease by the Cooperative Research Centre for Oral Health Science (CRC). Professor Eric Reynolds (also the head of Dental School at the University of Melbourne, Australia) and his Associate Professor Stuart Dashper are currently testing its ability as a Fumarate reductase inhibitor.

Fumarate reductase is an enzyme that has been found in the pathogenic bacteria in the biofilm in periodontal pockets. This bacteria has the ability to convert blood components into energy and for the bacteria to be virulent. Such bacteria would starve without this enzyme. As such, the role of the Oxantel as a fumarate reductase inhibitor would be to kill the bacteria responsible for periodontal disease.


v · d · eAntiparasitics – Anthelmintics (P02)
Antiplatyhelmintic agents
Antitrematodals
(schistosomicides)
Binds tubulin
Other/unknown
quinoline (Praziquantel#, Oxamniquine#) • phenol (Bithionol) • thiazole (Niridazole) • arylsulfonate (Stibophen)
Anticestodals
(taeniacides)
Binds tubulin
Other/unknown
salicylanilide (Niclosamide)# • aminoacridine (Quinacrine) • butyrophenone (Desaspidin) • chlorophenol (Dichlorophen)
Antinematodal agents
(including
macrofilaricides)
Binds tubulin
tetrahydropyrimidine (Pyrantel#, Pyrantel pamoate, Oxantel)
Other/unknown
piperazine (Piperazine • Diethylcarbamazine#) • thiazole (Levamisole#) • quinolinium (Pyrvinium) • benzylammonium (Bephenium) • naphthalenesulfonate (Suramin#)  • Tribendimidine

M: IFT

helm,arth (acar)

helm, arth (lice), zoon

helm, arth


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