p14arf

This article is about a tumor supressor gene. For ARF small GTP-binding protein, see ADP ribosylation factor.

cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
Identifiers
Symbol	CDKN2A
Alt. symbols	CDKN2, MLM
Entrez	1029
HUGO	1787
OMIM	600160
RefSeq	NM_000077
UniProt	P42771
Other data
Locus	Chr. 9 p21

p14ARF is an alternate reading frame (ARF) product of the CDKN2A locus. Both p16INK4a and p14ARF are involved in cell cycle regulation. p14ARF inhibits mdm2, thus promoting p53, which promotes p21 activation, which then binds and inactivates certain cyclin-CDK complexes, which would otherwise promote transcription of genes that would carry the cell through the G₁/S checkpoint of the cell cycle. Loss of p14ARF by a homozygous mutation in the CDKN2A (INK4A) gene will lead to elevated levels in mdm2 and, therefore, loss of p53 function and cell cycle control.

The equivalent in mice is p19ARF.

See also

• ARF tumor suppressor

External links

• MeSH Tumor+Suppressor+Protein+p14ARF