Kringle domain

Pfam_box
Symbol = Kringle
Name =

Kringle Domains are autonomous protein domains that fold into large loops stabilized by 3 disulfide linkages. These are important in protein-protein interactions with blood coagulation factors. The name Kringle comes from the Scandinavian pastry that these structures resemble.

Kringle domains have been found in plasminogen, hepatocyte growth factors, prothrombin, and apolipoprotein(a).

Kringles are found throughout the blood clotting and fibrinolytic proteins. Kringle domains are believed to play a role in binding mediators (e.g., membranes, other proteins or phospholipids), and in the regulation of proteolytic activitycite journal |author=Fujikawa K, McMullen BA |title=Amino acid sequence of the heavy chain of human alpha-factor XIIa (activated Hageman factor) |journal=J. Biol. Chem. |volume=260 |issue=9 |pages=5328–5341 |year=1985 |pmid=3886654] cite journal |author=Patthy L, Trexler M, Banyai L, Varadi A, Vali Z |title=Kringles: modules specialized for protein binding. Homology of the gelatin-binding regionof fibronectin with the kringle structures of proteases |journal=FEBS Lett. |volume=171 |issue=1 |pages=131–136 |year=1984 |pmid=6373375 |doi=10.1016/0014-5793(84)80473-1] cite journal |author=Atkinson RA, Williams RJ |title=Solution structureof the kringle 4 domain from human plasminogen by 1H nuclear magnetic resonance spectroscopy and distance geometry |journal=J. Mol. Biol. |volume=212 |issue=3 |pages=541–552 |year=1990 |pmid=2157850 |doi=10.1016/0022-2836(90)90330-O] . Kringle domainscite journal |author=Castellino FJ, Beals JM |title=The genetic relationships between the kringle domains of human plasminogen, prothrombin, tissue plasminogen activator, urokinase, and coagulation factor XII |journal=J. Mol. Evol. |volume=26 |issue=4 |pages=358–369 |year=1987 |pmid=3131537 |doi=10.1007/BF02101155] cite journal |author=Patthy L |title=Evolution of the proteases of blood coagulation and fibrinolysis by assembly from modules |journal=Cell |volume=41
issue=3 |pages=657–663 |year=1985 |pmid=3891096 |doi=10.1016/S0092-8674(85)80046-5] cite journal |author=Takahashi K, IkeoK, Gojobori T |title=Evolutionary origin of numerous kringles in human and simian apolipoprotein(a) |journal=FEBS Lett. |volume=287 |issue=1 |pages=146–148 |year=1991 |pmid=1879523 |doi=10.1016/0014-5793(91)80036-3] are characterised by a triple loop, 3-disulfide bridge structure, whose conformation is defined by a number of hydrogen bonds and small pieces of anti-parallel beta-sheet. They are found in a varying number of copies in some plasma proteins including prothrombin and urokinase-type plasminogenactivator, which are serine proteases belonging to MEROPS peptidase family S1A.

Human proteins containing this domain

ATF; F12; F2; HABP2; HGF; HGFAC; KREMEN1; KREMEN2;
LPA; LPAL2; MST1; PIK3IP1; PLAT; PLAU; PLG; PRSS12;
ROR1; ROR2;

References

External links

* [http://www.expasy.org/cgi-bin/nicedoc.pl?PDOC00020 Kringle domain] in PROSITE
* [http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=KR KR domain entry in the SMART database]

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kringle domain — kringle domain. См. домен «двойная петля». (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) … Молекулярная биология и генетика. Толковый словарь.
kringle domain — a cysteine rich, triply disulfide bonded sequence of amino acids folded into a characteristic shape resembling the looped Scandinavian pastry; such domains occur in plasminogen and contain the binding sites for fibrin. Similar domains are found… … Medical dictionary
Kringle — is a pastry developed in Scandinavia although some claim its roots are in Germany.In Danish and Norwegian the word is kringle , plural kringler ; Swedish: kringla , plural kringlor ; Icelandic: kringla , plural kringlur ; Finnish: rinkeli . The… … Wikipedia
kringle — A structural motif or domain seen in certain proteins in which a fold of large loops is stabilized by disulfide bonds; an important structural feature in blood coagulation factors. [Ger. Kringel, curl] * * * krin·gle (kringґgəl) see under… … Medical dictionary
Dominio Kringle — Saltar a navegación, búsqueda Fragmento 1 de la protrombina bovina en un complejo con calcio y lisofosfatidilserina. El dominio Kringle es un dominio de proteínas que se pliega en grandes bucles estabilizados por tres enlaces disulfuro. Estos… … Wikipedia Español
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домен «двойная петля» — kringle domain “kringle” домен, домен «двойная петля». Консервативный элемент вторичной структуры белков, в котором полипептидная цепь уложена в виде характерной двойной петли («петля в петле») с участием трех дисульфидных связей. В молекуле… … Молекулярная биология и генетика. Толковый словарь.

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Kringle domain

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