Diethylcarbamazine

Diethylcarbamazine

Systematic (IUPAC) name
N,N-diethyl-4-methylpiperazine-1-carboxamide
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	?
Legal status	Legal
Pharmacokinetic data
Half-life	.
Identifiers
CAS number	90-89-1
ATC code	P02CB02 QP52AH02
PubChem	CID 3052
DrugBank	DB00711
ChemSpider	2944 Y
UNII	V867Q8X3ZD Y
KEGG	D07825 Y
ChEMBL	CHEMBL684 Y
Chemical data
Formula	C10H21N3O
Mol. mass	199.293 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C10H21N3O/c1-4-12(5-2)10(14)13-8-6-11(3)7-9-13/h4-9H2,1-3H3 Y Key:RCKMWOKWVGPNJF-UHFFFAOYSA-N Y
Y(what is this?)  (verify)

Diethylcarbamazine (DEC) is an anthelmintic drug that does not resemble other antiparasitic compounds. It is a synthetic organic compound which is highly specific for several parasites and does not contain any toxic metallic elements.

Uses

DEC is indicated for treatment of individual patients with certain filarial diseases. These diseases include: lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori; tropical pulmonary eosinophilia, and loiasis.

In cases of onchocerciasis, another common filarial parasite, the drug is not used. This is because of the intense and unbearable itching associated with the dead subcutaneous parasites.

DEC continues to be the mainstay for treatment of patients with lymphatic filariasis and loiasis. DEC is also used in the prevention of dog heartworm Dirofilaria immitis.

Mechanism

DEC is an inhibitor of arachidonic acid metabolism in filarial microfilaria. This makes the microfilaria more susceptible to immune attack.

Trade names

• Hetrazan
• Carbilazine
• Caricide
• Cypip
• Ethodryl
• Notézine
• Spatonin
• Filaribits
• Banocide Forte

This medical treatment-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Antiparasitic agents Piperazines Ureas Medical treatment stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Anthelmintic Naseby Look at other dictionaries: diethylcarbamazine — /duy eth euhl kahr bam euh zeen /, n. Pharm. an anthelmintic, C10H21N3O, used in the treatment of various filarial worm infestations, esp. those of the genera Wuchereria, Loa, and Onchocerca. [1965 70; DI 1 + ETHYL + CARBAM(YL) + (PIPER)AZINE] *… …   Universalium diethylcarbamazine — noun Etymology: di + ethyl + carboxy + amide + azine Date: 1948 an anthelmintic administered in the form of its crystalline citrate C10H21N3O•C6H8O7 especially to control human filariasis and large nematodes (as heartworms) i …   New Collegiate Dictionary diethylcarbamazine — di·eth·yl·car·bam·azine .dī .eth əl kär bam ə .zēn, zən n an anthelmintic derived from piperazine and administered in the form of its crystalline citrate C10H21N3O·C6H8O7 esp. to control filariasis in humans and large roundworms in dogs and cats… …   Medical dictionary diethylcarbamazine — di·eth·yl·car·bam·a·zine …   English syllables diethylcarbamazine — n. an anthelmintic drug that destroys filariae and is therefore used in the treatment of filariasis and loiasis. It is administered as tablets. Side effects may include headache, malaise, joint pains, nausea, and vomiting …   The new mediacal dictionary diethylcarbamazine — ˌdīˌethə̇lˌkärˈbaməˌzēn, zə̇n noun : an anthelmintic derived from piperazine and administered in the form of its crystalline citrate C10H21N3O.C6H8O7 * * * /duy eth euhl kahr bam euh zeen /, n. Pharm. an anthelmintic, C10H21N3O, used in the… …   Useful english dictionary diethylcarbamazine citrate — An effective microfilaricide, although relatively ineffective against the adult filariae …   Medical dictionary Filariose De Bancroft — La filariose lymphatique est une maladie tropicale, infectieuse et plus précisément parasitaire provoquée par des vers parasites du genre filaire Wuchereria bancrofti, Brugia malayi et Brugia timori, toutes transmises par les moustiques. C’est… …   Wikipédia en Français Filariose de Bancroft — La filariose lymphatique, est une maladie tropicale, infectieuse et plus précisément parasitaire provoquée par des vers parasites du genre filaire Wuchereria bancrofti (filariose de Bancroft), Brugia malayi (filariose de Malaisie) et Brugia… …   Wikipédia en Français Filariose de bancroft — La filariose lymphatique est une maladie tropicale, infectieuse et plus précisément parasitaire provoquée par des vers parasites du genre filaire Wuchereria bancrofti, Brugia malayi et Brugia timori, toutes transmises par les moustiques. C’est… …   Wikipédia en Français 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”