Swain equation

Swain equation

The Swain equation relates the kinetic isotope effect for the proton/tritium combination with that of the proton/deuterium combination according to:

:frac{k_H}{k_T} = frac{k_H}{k_D}^{1.442}

where kH,D,T is the reaction rate constant for the protonated, deuterated and tritiated reactants.

External links

# [http://emsp.em.doe.gov/EMSPprojects1996_2002/completed/55103.pdf Applied Swain equation]

References

# "Use of Hydrogen Isotope Effects to Identify the Attacking Nucleophile in the Enolization of Ketones Catalyzed by Acetic Acid" C. Gardner Swain, Edward C. Stivers, Joseph F. Reuwer, , Jr. Lawrence J. Schaad; J. Am. Chem. Soc.; 1958; 80(21); 5885-5893. [http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1958/80/i21/f_ja01554a077.pdf First Page]


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