TRAIL

TRAIL

TNF-related apoptosis-inducing ligand (TRAIL), in the field of cell biology, is a ligand molecule which induces the process of cell death called apoptosis. It is a type II transmembrane protein with homology to other members of the tumor necrosis factor family.

In humans, the gene that encodes for TRAIL is located at chromosome 3q26.

TRAIL binds to the death receptors, DR4 and DR5. The process of apoptosis is caspase-8-dependent.

TRAIL has also been designated CD253 (cluster of differentiation 253).

Further reading

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citations =
*cite journal | author=Almasan A, Ashkenazi A |title=Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy. |journal=Cytokine Growth Factor Rev. |volume=14 |issue= 3-4 |pages= 337–48 |year= 2004 |pmid= 12787570 |doi=
*cite journal | author=Cha SS, Song YL, Oh BH |title=Specificity of molecular recognition learned from the crystal structures of TRAIL and the TRAIL:sDR5 complex. |journal=Vitam. Horm. |volume=67 |issue= |pages= 1–17 |year= 2004 |pmid= 15110168 |doi= 10.1016/S0083-6729(04)67001-4
*cite journal | author=Song C, Jin B |title=TRAIL (CD253), a new member of the TNF superfamily. |journal=J. Biol. Regul. Homeost. Agents |volume=19 |issue= 1-2 |pages= 73–7 |year= 2005 |pmid= 16178278 |doi=
*cite journal | author=Bucur O, Ray S, Bucur MC, Almasan A |title=APO2 ligand/tumor necrosis factor-related apoptosis-inducing ligand in prostate cancer therapy. |journal=Front. Biosci. |volume=11 |issue= |pages= 1549–68 |year= 2006 |pmid= 16368536 |doi=

External links

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