Sulbactam

drugbox
IUPAC_name = (2"R",5"R")-3,3-dimethyl-4,4,7-trioxo-4λ⁶-thia-1-
azabicyclo [3.2.0] heptane-2-carboxylic acid

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width = 150px
CAS_number = 68373-14-8
ATC_prefix = J01
ATC_suffix = CG01
PubChem = 130313
DrugBank =
C = 8 | H = 11 | N = 1 | O = 5 | S = 1
molecular_weight = 233.243 g/mol
bioavailability = 1
protein_bound =
metabolism =
elimination_half-life =
excretion = Kidneys?
pregnancy_AU =
pregnancy_US =
pregnancy_category =
legal_AU =
legal_CA =
legal_UK = POM
legal_US =
legal_status =
routes_of_administration = Injection

Sulbactam is a molecule which is given in combination with beta-lactam antibiotics to inhibit beta-lactamase, an enzyme produced by bacteria that destroys the antibiotics. Sulbactam is an irreversible inhibitor of beta-lactamase; it binds the enzyme and does not allow it to interact with the antibiotic. Sulbactam is able to inhibit the most common forms of beta-lactamase but is not able to interact with the ampC cephalosporinase. Thus, it confers little protection against bacteria such as "Pseudomonas aeruginosa", "Citrobacter", "Enterobacter", and "Serratia", which often express this gene. In the United States, sulbactam is combined to form cefoperazone/sulbactam and ampicillin/sulbactam. It does possess some antibacterial activity when administered alone, but it is too weak to have any clinical importance. Its use in the UK is restricted to hospitals.

References

*Singh GS. "Beta-lactams in the new millennium. Part-II: cephems, oxacephems, penams and sulbactam." Mini Rev Med Chem. 2004 Jan;4(1):93-109. Review. PMID 14754446