Male-limited precocious puberty

Male-limited precocious puberty
Male-limited precocious puberty
Classification and external resources
OMIM 176410

Male-limited precocious puberty (also known as familial sexual precocity and gonadotropin-independent testotoxicosis)[1] is a form of gonadotropin-independent precocious puberty in which boys experience early onset and progression of puberty.[2] Signs of puberty can develop as early as an age of 1 year.

The spinal length in boys may be short due to a rapid advance in epiphyseal maturation. It is an autosomal dominant[1] condition with a mutation of the LH receptor. Treatment is with drugs that suppress gonadal steroidogenesis, such as cyproterone acetate, ketoconazole or spironolactone and testolactone.[3]

Male-limited precocious puberty has an autosomal dominant pattern of inheritance.

References

  1. ^ a b Online 'Mendelian Inheritance in Man' (OMIM) 176410
  2. ^ Traggiai C, Stanhope R (2003). "Disorders of pubertal development". Best Pract Res Clin Obstet Gynaecol 17 (1): 41–56. doi:10.1053/ybeog.2003.0360. PMID 12758225. 
  3. ^ Reiter EO, Norjavaara E (2005). "Testotoxicosis: current viewpoint". Pediatr Endocrinol Rev 3 (2): 77–86. PMID 16361981. 

External links


Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • Luteinizing hormone/choriogonadotropin receptor — The luteinizing hormone/choriogonadotropin receptor (LHCGR), also lutropin/choriogonadotropin receptor (LCGR) is a transmembrane receptor found in ovary, testis and extragonodal organs like uterus, that receptor interacts with both luteinizing… …   Wikipedia

  • List of diseases (P) — A list of diseases in the English Wikipedia.DiseasesTOC PaPac Pal* Pachydermoperiostosis * Pachygyria * Pachyonychia congenita Jackson Lawler type * Pacman dysplasia * Paes Whelan Modi syndrome * Paget disease extramammary * Paget disease… …   Wikipedia

  • Congenital hypothyroidism — Classification and external resources ICD 10 E00, E03.0, E03.1 …   Wikipedia

  • Hereditary hemorrhagic telangiectasia — Classification and external resources Characteristic lip telangiectases. ICD 10 I …   Wikipedia

  • Thanatophoric dysplasia — Classification and external resources ICD 10 Q77.1 OMIM 187600 DiseasesDB …   Wikipedia

  • Robinow syndrome — Classification and external resources An infant exhibiting the facial features of Robinow syndrome. ICD 10 Q …   Wikipedia

  • Genetic disorder — For a non technical introduction to the topic, see Introduction to genetics. Genetic disorder Classification and external resources MeSH D030342 A genetic disorder is an illness caused by abnormalities in genes or …   Wikipedia

  • Donohue syndrome — Classification and external resources insulin receptor OMIM 246200 …   Wikipedia

  • Hirschsprung's disease — Classification and external resources Histopathology of Hirschsprung disease. Enzyme histochemistry showing aberrant acetylcholine esterase (ACHE) positive fibres (brown) in the lamina propria mucosae …   Wikipedia

  • Osteopetrosis — (Malignant) Classification and external resources X ray of the pelvis of a patient with osteopetrosis, adult onset form (Albers Schonberg disease). Note the dense bones. ICD …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”