- Nelson's syndrome
Nelson's syndrome Classification and external resources ICD-10 E24.1 DiseasesDB 8863 eMedicine ped/1558
Removal of both adrenal glands, or bilateral adrenalectomy, is an operation for Cushing's syndrome. Removal of both adrenals eliminates production of cortisol, and the lack of cortisol's negative feedback can allow any preexisting pituitary adenoma to grow unchecked. Continued growth can cause mass effects due to physical compression of brain tissue, along with increased production of adrenocorticotrophic hormone (ACTH) and melanocyte stimulating hormone (MSH).
The common signs and symptoms include muscle weakness and skin hyperpigmentation due to excess MSH. Nelson's syndrome is now rare because bilateral adrenalectomy is now only used in extreme circumstances.
Pituitary surgery is performed in some cases. The risk can also be minimized by pituitary irradiation.
The condition is named for the American endocrinologist Dr Don Nelson, who first reported on the phenomenon in 1960.
- ^ Biller BM, Grossman AB, Stewart PM, et al. (July 2008). "Treatment of adrenocorticotropin-dependent Cushing's syndrome: a consensus statement". J. Clin. Endocrinol. Metab. 93 (7): 2454–62. doi:10.1210/jc.2007-2734. PMID 18413427. http://jcem.endojournals.org/cgi/content/full/93/7/2454.
- ^ Kelly PA, Samandouras G, Grossman AB, Afshar F, Besser GM, Jenkins PJ (December 2002). "Neurosurgical treatment of Nelson's syndrome". J. Clin. Endocrinol. Metab. 87 (12): 5465–9. doi:10.1210/jc.2002-020299. PMID 12466338. http://jcem.endojournals.org/cgi/pmidlookup?view=long&pmid=12466338.
- ^ Nelson D, Meakin J, Thorn G (1960). "ACTH-producing pituitary tumors following adrenalectomy for Cushing's syndrome". Ann Intern Med 52: 560–9. PMID 14426442.
Endocrine pathology: endocrine diseases (E00–E35, 240–259) Pancreas/
pituitary axesHypothalamusPituitaryThyroidEndemic goitre · Toxic nodular goitre · Toxic multinodular goiter
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Nelson's syndrome — a condition in which an ACTH producing pituitary tumour develops after loss of negative feedback following bilateral adrenalectomy, usually for Cushing s syndrome. D. H. Nelson (1925 ), US physician … Medical dictionary
Nelson's syndrome — a condition in which an ACTH producing pituitary tumour develops after loss of negative feedback following bilateral adrenalectomy, usually for Cushing s syndrome. [D. H. Nelson (1925– ), US physician] … The new mediacal dictionary
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Nelson syndrome — Nel·son syndrome (nelґsən) [Don H. Nelson, American internist, born 1925] see under syndrome … Medical dictionary
syndrome — The aggregate of symptoms and signs associated with any morbid process, and constituting together the picture of the disease. SEE ALSO: disease. [G. s., a running together, tumultuous concourse; (in med.) a concurrence of symptoms, fr. syn,… … Medical dictionary
Nelson syndrome — the development of an ACTH producing pituitary tumor after bilateral adrenalectomy for Cushing syndrome; it is characterized by aggressive growth of the tumor and hyperpigmentation of the skin … Medical dictionary
Nelson — Don H., U.S. internist, *1925. See N. syndrome, N. tumor … Medical dictionary
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