Class I PI 3-kinases

Class I PI 3-kinases

Class I PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that possess a common protein domain structure, substrate specificity, and method of activation. Class I PI 3-kinases are further divided into two subclasses, class IA PI 3-kinases and class IB PI 3-kinases.

Contents

Class IA PI 3-kinases

Class IA PI 3-kinases are activated by receptor tyrosine kinases (RTKs).

There are three catalytic subunits that are classified as class IA PI 3-kinases:

There are currently five regulatory subunits that are known to associate with class IA PI 3-kinases catalytic subunits:

  • p85α and p85β
  • p55α and p55γ
  • p50α

Class IB PI 3-kinases

Class IB PI 3-kinases are activated by G-protein-coupled receptors (GPCRs).

The only known class IB PI 3-kinase catalytic subunit is p110γ.

There are two known regulatory subunits for p110γ:

See also

References

  • Foster FM, Traer CJ, Abraham SM, Fry MJ (August 2003). "The phosphoinositide (PI) 3-kinase family". J. Cell. Sci. 116 (Pt 15): 3037–40. doi:10.1242/jcs.00609. PMID 12829733. 


v · d · eTransferases: phosphorus-containing groups (EC 2.7)
2.7.1-2.7.4:
phosphotransferase/kinase
(PO4)
2.7.1: OH acceptor
2.7.2: COOH acceptor
2.7.3: N acceptor
2.7.4: PO4 acceptor
2.7.6: diphosphotransferase
(P2O7)
2.7.7: nucleotidyltransferase
(PO4-nucleoside)

DNA-directed DNA polymerase: DNA polymerase I · DNA polymerase II · DNA polymerase III holoenzyme
RNA-directed DNA polymerase: Reverse transcriptase (Telomerase)

DNA nucleotidylexotransferase/Terminal deoxynucleotidyl transferase
RNA nucleotidyltransferase
Uridylyltransferase
Glucose-1-phosphate uridylyltransferase · Galactose-1-phosphate uridylyltransferase
Guanylyltransferase
mRNA capping enzyme
Other
2.7.8: miscellaneous
Phosphatidyltransferases
CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase · CDP-diacylglycerol—serine O-phosphatidyltransferase · CDP-diacylglycerol—inositol 3-phosphatidyltransferase · CDP-diacylglycerol—choline O-phosphatidyltransferase
Glycosyl-1-phosphotransferase
2.7.10-2.7.13: protein kinase
(PO4; protein acceptor)
see tyrosine kinases
see serine/threonine-specific protein kinases
2.7.12: protein-dual-specificity
see serine/threonine-specific protein kinases
2.7.13: protein-histidine
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

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