Thrombotic microangiopathy
- Thrombotic microangiopathy
Infobox_Disease
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ICD10 = ICD10|M|31|1|m|30
ICD9 = ICD9|446.6
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Thrombotic microangiopathies are a category of pathologies that result in thrombosis in capillaries and arterioles. This process leads to thrombocytopenia and a variety of other symptoms such as: anemia, purpura, renal failure (some), schistocytes (fragmented blood cells severed by fibrin products) and ischemic injury to cells.
Categories
Bacterial toxins are the primary cause of one category of thrombotic microangiopathy known as HUS or hemolytic uremic syndrome. The other major category is TTP or thrombotic thrombocytopenic purpura caused by autoimmune or hereditary dysfunctions that activate the coagulation cascade or the complement system.
Some sources group TTP and HUS together [http://www.merck.com/mmpe/sec11/ch133/ch133g.html] , while other sources express skepticism about their common pathophysiology. [http://www.emedicine.com/emerg/topic579.htm]
Presentation
The clinical presentation typically includes: fever, microangiopathic hemolytic anemia (see schistocytes in a blood smear), renal failure, thrombocytopenia, neurological manifestations.
References
Wikimedia Foundation.
2010.
Look at other dictionaries:
thrombotic microangiopathy — the formation of thrombi in the arterioles and capillaries; some authorities propose this as a name for a single syndrome that would include both thrombotic thrombocytopenic purpura and hemolytic uremic syndrome … Medical dictionary
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Bevacizumab — drugbox type = mab source = Human target = VEGF CAS number=216974 75 3 ATC prefix=L01 ATC suffix=XC07 PubChem=(none) DrugBank=BTD00087 molecular weight = approx. 149,000 kDa bioavailability= 100% (IV only) metabolism = ? elimination half life= 20 … Wikipedia
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hemolytic uremic syndrome — n any of a group of rare disorders that are characterized by microangiopathic hemolytic anemia, thrombocytopenia, and varying degrees of kidney failure, that are precipitated by a variety of etiologic factors (as infection with toxin producing… … Medical dictionary
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