Fumarase

Fumarase

protein
Name=fumarate hydratase
caption=


width=
HGNCid=3700
Symbol=FH
AltSymbols=
EntrezGene=2271
OMIM=136850
RefSeq=NM_000143
UniProt=P07954
PDB=
ECnumber=4.2.1.2
Chromosome=1
Arm=q
Band=42.1
LocusSupplementaryData=

Fumarase (or fumarate hydratase) is an enzyme involved in the Krebs Cycle (aka the Tricarboxylic Acid Cycle aka the Citric Acid Cycle) that catalyzes the hydration (addition of H2O across a double bond) of Fumarate to L-malate (See the entry on optical isomer).

Fumarate + H2O <-> L Malate

Biochemical Pathway

* Diagram [http://www.genome.jp/kegg/pathway/map/map00020.html TCA Cycle] at [http://www.gehome.jp/kegg KEGG] , gives some details on the TCA cycle in which fumerase acts. [Fumarase is labeled '4.2.1.2' in the lower left hand corner of this diagram.

* [http://www.biocheminfo.org/klotho/html/fumarate.html structure of Fumarate]
* [http://www.biocheminfo.org/klotho/html/L-malate.html Structure of L Malate]

* See also Citric Acid Cycle on Wikipedia.

ee also

*Fumarase deficiency

External links

* [http://www.rcsb.org/pdb/explore.do?structureId=1YFM Crystal structure of Yeast Fumarase] at the Protein Data Bank.
*


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Look at other dictionaries:

  • Fumarase — Modell des Tetramer der menschlichen Fumarase nach PDB  …   Deutsch Wikipedia

  • fumarase — fumarase. См. фумараза. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • fumarase — [fymaʀaz] n. m. ÉTYM. XXe; de fumarique, et ase. ❖ ♦ Chim. Enzyme catalysant l hydratation de l acide fumarique en acide malique (d après J. Monod, le Hasard et la Nécessité, p. 71) …   Encyclopédie Universelle

  • Fumarase deficiency — Infobox Disease Name = PAGENAME Caption = Fumarate is converted to malate by fumarase Width = 72px DiseasesDB = 29835 ICD10 = ICD9 = ICDO = OMIM = 606812 MedlinePlus = eMedicineSubj = eMedicineTopic = MeshID = Fumarase deficiency (or fumaric… …   Wikipedia

  • fumarase — noun Date: 1936 an enzyme that catalyzes the interconversion (as in the Krebs cycle) of fumaric acid and malic acid or their salts …   New Collegiate Dictionary

  • fumarase — noun An enzyme that in the Krebs cycle acts as a catalyst for the reaction of water and fumarate to form L malate …   Wiktionary

  • fumarase — SYN: fumarate hydratase. * * * fu·ma·rase fyü mə .rās, .rāz n an enzyme that catalyzes the interconversion (as in the Krebs cycle) of fumaric acid and malic acid or their salts * * * fu·ma·rase (fuґmə rās) fumarate hydratase …   Medical dictionary

  • Fumarase — Fu|ma|ra|se [↑ Fumar u. ↑ ase], die; ; Syn.: Fumarat Hydratase: in lebenden Zellen weitverbreitete Hydratase, die im Citronensäurezyklus die ↑ Hydratisierung von Fumarsäure zu Apfelsäure katalysiert …   Universal-Lexikon

  • fumarase — fu·ma·rase …   English syllables

  • fumarase — ˈfyüməˌrās, āz noun ( s) Etymology: International Scientific Vocabulary fumar + ase : a crystalline enzyme occurring in many animal and plant tissues that accelerates the interconversion of fumaric acid and l malic acid by hydration and… …   Useful english dictionary

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