Dermatan sulfate

Dermatan sulfate
Dermatan sulfate
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 24967-94-0
ATC code B01AX04
ChemSpider 30361 YesY
Chemical data
Formula  ?
SMILES eMolecules & PubChem
 YesY(what is this?)  sulfate (verify)

Dermatan sulfate is a glycosaminoglycan (formerly called a mucopolysaccharide) found mostly in skin, but also in blood vessels, heart valves, tendons, and lungs.

It is also referred to as chondroitin sulfate B, [1] although it is no longer classified as a form of chondroitin sulfate by most sources.

Contents

Function

Dermatan sulfate may have roles in coagulation, cardiovascular disease, carcinogenesis, infection, wound repair, and fibrosis.[2]

Pathology

Dermatan sulfate accumulates abnormally in several of the mucopolysaccharidosis disorders.

An excess of Dermatan Sulfate in the Mitral Valve is characteristic of myxomatous degeneration of the leaflets leading to redundancy of valve tissue and ultimately, Mitral Valve Prolapse (into the Left atrium) and insufficiency. This chronic prolapse occurs mainly in women over the age of 60, and can predispose the patient to mitral annular calcification. Mitral valve insufficiency can lead to eccentric (volume dependent or dilated) hypertrophy and eventually Left Heart failure if untreated.

See also

External links

References

  1. ^ Trowbridge, JM; Gallo, RL (September 2002). "Dermatan sulfate: new functions from an old glycosaminoglycan". Glycobiology 12 (9): 117R–25R. doi:10.1093/glycob/cwf066. PMID 12213784. 
  2. ^ Janet M. Trowbridge and Richard L. Gallo (2002). "Dermatan sulfate: new functions from an old glycosaminoglycan". pp. 117R-125R. doi:10.1093/glycob/cwf066. http://glycob.oxfordjournals.org/content/12/9/117R.short. 



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Look at other dictionaries:

  • dermatan sulfate — der·ma·tan sul·fate (dur″mə tan) a glycosaminoglycan found mostly in the skin but also in blood vessels, tendons, heart valves, and pulmonary connective tissues. It consists of repeating disaccharide units in specific linkage, each… …   Medical dictionary

  • sulfate — A salt or ester of sulfuric acid. acid s. SYN: bisulfate. active s. SYN: adenosine 3′ phosphate 5′ phosphosulfate. s. adenylyltransferase an enzyme that catalyzes a step in the pathway for the synthesis of active s.; the enzyme reacts ATP wit …   Medical dictionary

  • Chondroitin sulfate — Chemical structure of one unit in a chondroitin sulfate chain. Chondroitin 4 sulfate: R1 = H; R2 = SO3H; R3 = H. Chondroitin 6 sulfate: R1 = SO3H; R2, R3 = H …   Wikipedia

  • Heparan sulfate — (HS) is a linear polysaccharide found in all animal tissues. It occurs as a proteoglycan (PG) in which two or three HS chains are attached in close proximity to cell surface or extracellular matrix proteins. [cite book | title=Proteoglycans:… …   Wikipedia

  • chondroitin sulfate — n any of several sulfated forms of chondroitin found in various tissues (as cartilage, adult bone, and tendons) * * * chon·dro·i·tin sul·fate (kon droґĭ tin) 1. a glycosaminoglycan that predominates in the ground substance of cartilage, bone …   Medical dictionary

  • Chondroitin sulfate proteoglycan — Chondroitin sulfate proteoglycans (CSPGs) are proteoglycans[1] consisting of a core protein and chondroitin sulfate. They are structural components of a variety of human tissues, for example of cartilage. The following CSPGs have been identified …   Wikipedia

  • Chondroitin-sulfate-ABC endolyase — Identifiers EC number 4.2.2.20 Databases IntEnz IntEnz view …   Wikipedia

  • Chondroitin-sulfate-ABC exolyase — Identifiers EC number 4.2.2.21 Databases IntEnz IntEnz view …   Wikipedia

  • DSE (gene) — Dermatan sulfate epimerase Identifiers Symbols DSE; DSEPI; SART2 External IDs OMIM …   Wikipedia

  • CHST14 — Dermatan 4 sulfotransferase 1, also known as D4ST1, is a human gene.cite web | title = Entrez Gene: D4ST1 dermatan 4 sulfotransferase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=113189| accessdate = ] …   Wikipedia

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