Haplogroup O (Y-DNA)

In human genetics, Haplogroup O (M175) is a Y-chromosome DNA haplogroup.

Distribution

This haplogroup appears in 80-90% of all men in East and Southeast Asia, and it is almost exclusive to that region: M175 is almost nonexistent in Western Siberia, Western Asia, and Europe and is completely absent from Africa and the Americas, although certain subclades of Haplogroup O do achieve significant frequencies among some populations of South Asia, Central Asia, and Oceania.

Origins

Haplogroup O is a descendant haplogroup of Haplogroup NO (M214), and is believed to have first appeared in Siberia or eastern Central Asia approximately 35,000 years ago. Haplogroup O shares a node in the phylogenetic tree of human Y-chromosomes with Haplogroup N, which is common throughout North Eurasia.

Subgroups

The subclades of Haplogroup O with their defining mutation, according to the 2008 ISOGG tree:

*O (M175)
**O*
**O1 (MSY2.2)
***O1*
***O1a (M119) "Typical of Austronesians, southern Han Chinese, and Tai-Kadai peoples"
****O1a*
****O1a1 (P203)
*****O1a1*
*****O1a1a (M101)
****O1a2 (M50, M103, M110)
**O2 (P31, M268)
***O2*
***O2a (M95) "Typical of Austro-Asiatic peoples, Tai-Kadai peoples, Malays, and Indonesians, with a moderate distribution throughout South Asia, Southeast Asia, East Asia, and Central Asia"
****O2a*
****O2a1 (M88, M111) "Frequently found among Hani, She people, Tai peoples, Cambodians, and Vietnamese, with a moderate distribution among Qiang, Yi, Hlai, Miao, Yao, Taiwanese aborigines, and Han Chinese of Sichuan, Guangxi, and Guangdong"
*****O2a1*
*****O2a1a (PK4) "Found at low frequency among Pashtuns" [ [http://www.nature.com/ejhg/journal/v15/n1/full/5201726a.html Y-chromosomal evidence for a limited Greek contribution to the Pathan population of Pakistan] , Sadaf Firasat, Shagufta Khaliq, Aisha Mohyuddin, Myrto Papaioannou, Chris Tyler-Smith, Peter A Underhill and Qasim Ayub, "European Journal of Human Genetics" (2007) 15, 121–126]
****O2a2 (M297)
***O2b (M176/SRY465, P49, 022454)
****O2b* "Typical of Koreans, with a moderate distribution among Ryukyuans, Japanese, Indonesians, Vietnamese, Thais, Manchus, Evenks, and Micronesians"
****O2b1 (47z) "Typical of Japanese and Ryukyuans, with a moderate distribution among Indonesians, Thais, Koreans, and Vietnamese"
**O3 (M122) "Typical of populations of East Asia, Southeast Asia, and culturally Austronesian regions of Oceania, with a moderate distribution in Central Asia"
***O3*
***O3a (M324, P93, P197, P198, P199, P200)
****O3a*
****O3a1 (DYS257/P27.2, M121)
****O3a2 (M164)
****O3a3 (P201/021354)
*****O3a3*
*****O3a3a (M159)
*****O3a3b (M7) "Typical of Hmong-Mien peoples, with a moderate distribution among Han Chinese, Buyei, Qiang, and Oroqen"Yali Xue, Tatiana Zerjal, Weidong Bao, Suling Zhu, Qunfang Shu, Jiujin Xu, Ruofu Du, Songbin Fu, Pu Li, Matthew E. Hurles, Huanming Yang, and Chris Tyler-Smith, "Male Demography in East Asia: A North–South Contrast in Human Population Expansion Times," "Genetics" 2006 April; 172(4): 2431–2439.]
******O3a3b*
******O3a3b1 (M113, M188, M209)
*******O3a3b1*
*******O3a3b1a (N4)
*******O3a3b1b (N5)
******O3a3b2 (P164)
*****O3a3c (M134) "Typical of Sino-Tibetan peoples, with a moderate distribution throughout East Asia and Southeast Asia"
******O3a3c*
******O3a3c1 (M117, M133)
*******O3a3c1*
*******O3a3c1a (M162)
******O3a3c2 (P101)
****O3a4 (002611)
*****O3a4*
*****O3a4a (P103)
****O3a5 (M300)
****O3a6 (M333)

Among the subbranches of Haplogroup O are Haplogroup O1, Haplogroup O2, and Haplogroup O3.

Haplogroup O* lineages, which belong to Haplogroup O but do not display any of the later mutations that define the major subclades O1, O2, and O3, can still be detected at a low frequency among most modern populations of Central Asia and East Asia. For example, a broad survey of Y-chromosome variation among populations of central Eurasia found haplogroup O-M175*(xO1a-M119,O2a-M95,O3-M122) in 2.5% (one out of 40 individuals) of a sample of Tajiks in Samarkand, 4.5% (1/22) of Crimean Tatars in Uzbekistan, 1.5% (1/68) of Uzbeks in Surkhandarya, 1.4% (1/70) of Uzbeks in Khorezm, 6.3% (1/16) of Tajiks in Dushanbe, 1.9% (1/54) of Kazakhs in Kazakhstan, 4.9% (2/41) of Uyghurs in Kazakhstan, and 31.1% (14/45) of Koreans. [R. Spencer Wells, Nadira Yuldasheva, Ruslan Ruzibakiev, Peter A. Underhill, Irina Evseeva, Jason Blue-Smith, Li Jin, Bing Su, Ramasamy Pitchappan, Sadagopal Shanmugalakshmi, Karuppiah Balakrishnan, Mark Read, Nathaniel M. Pearson, Tatiana Zerjal, Matthew T. Webster, Irakli Zholoshvili, Elena Jamarjashvili, Spartak Gambarov, Behrouz Nikbin, Ashur Dostiev, Ogonazar Aknazarov, Pierre Zalloua, Igor Tsoy, Mikhail Kitaev, Mirsaid Mirrakhimov, Ashir Chariev, and Walter F. Bodmer: "The Eurasian Heartland: A continental perspective on Y-chromosome diversity." "Proceedings of the National Academy of Sciences of the United States of America" v.98(18); Aug 28, 2001] However, nearly all of these Korean O*(xO1a,O2a,O3) Y-chromosomes probably belong to Haplogroup O2b, which has been found in approximately 30% of many samples of Koreans. There is also a possibility that the so-called Haplogroup O* Y-chromosomes that have been found among these populations might belong to Haplogroup O1*(xO1a-M119), Haplogroup O2*(xO2a-M95,O2b-M176), or Haplogroup O2b-M176.

References

External links

* [http://www.explore-qatar.com/archives/all_qatar_today_articles/archive-186.htm Migration patterns of early Humans] and [http://www.explore-qatar.com/imglib/spencer_4.jpgthe full size map]

* [https://www3.nationalgeographic.com/genographic/atlas.html?card=my042 Spread of Haplogroup O] , from The Genographic Project, "National Geographic"

* [http://www.facebook.com/group.php?gid=6831026431 China DNA] interest group on Facebook

* [http://www.familytreedna.com/public/china China DNA] at Family Tree DNA

* [http://www.facebook.com/group.php?gid=6153169411 Haplogroup O (Y-DNA)] interest group on Facebook