Interleukin 7

Interleukin 7 (IL7) is a hematopoietic growth factor secreted by the stromal cells of the red marrow and thymus capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation, T and NK cell survival, development and homeostasis (From UniProt IL7_HUMAN).

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. [cite web | title = Entrez Gene: IL7 interleukin 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3574| accessdate = ]

References

Further reading

* [http://bloodjournal.hematologylibrary.org/cgi/content/full/99/11/3892 Terry J. Fry and Crystal L. Mackall, "Interleukin-7: from bench to clinic", "Blood," Vol. 99, No. 11, pp. 3892-3904. Review article (1 June 2002)] PBB_Further_reading
citations =
*cite journal | author=Möller P, Böhm M, Czarnetszki BM, Schadendorf D |title=Interleukin-7. Biology and implications for dermatology |journal=Exp. Dermatol. |volume=5 |issue= 3 |pages= 129–37 |year= 1997 |pmid= 8840152 |doi=
*cite journal | author=Appasamy PM |title=Biological and clinical implications of interleukin-7 and lymphopoiesis |journal=Cytokines Cell. Mol. Ther. |volume=5 |issue= 1 |pages= 25–39 |year= 1999 |pmid= 10390077 |doi=
*cite journal | author=Fry TJ, Mackall CL |title=Interleukin-7: from bench to clinic |journal=Blood |volume=99 |issue= 11 |pages= 3892–904 |year= 2002 |pmid= 12010786 |doi=
*cite journal | author=Fry TJ, Mackall CL |title=Interleukin-7 and immunorestoration in HIV: beyond the thymus |journal=J. Hematother. Stem Cell Res. |volume=11 |issue= 5 |pages= 803–7 |year= 2003 |pmid= 12427286 |doi= 10.1089/152581602760404603
*cite journal | author=Al-Rawi MA, Mansel RE, Jiang WG |title=Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours |journal=Histol. Histopathol. |volume=18 |issue= 3 |pages= 911–23 |year= 2004 |pmid= 12792903 |doi=
*cite journal | author=Aspinall R, Henson S, Pido-Lopez J, Ngom PT |title=Interleukin-7: an interleukin for rejuvenating the immune system |journal=Ann. N. Y. Acad. Sci. |volume=1019 |issue= |pages= 116–22 |year= 2004 |pmid= 15247003 |doi= 10.1196/annals.1297.021
*cite journal | author=Snyder KM, Mackall CL, Fry TJ |title=IL-7 in allogeneic transplant: clinical promise and potential pitfalls |journal=Leuk. Lymphoma |volume=47 |issue= 7 |pages= 1222–8 |year= 2007 |pmid= 16923550 |doi= 10.1080/10428190600555876
*cite journal | author=Brunton LL, Lupton SD |title=An STS in the human IL7 gene located at 8q12-13 |journal=Nucleic Acids Res. |volume=18 |issue= 5 |pages= 1315 |year= 1990 |pmid= 2320434 |doi=
*cite journal | author=Lupton SD, Gimpel S, Jerzy R, "et al." |title=Characterization of the human and murine IL-7 genes |journal=J. Immunol. |volume=144 |issue= 9 |pages= 3592–601 |year= 1990 |pmid= 2329282 |doi=
*cite journal | author=Goodwin RG, Lupton S, Schmierer A, "et al." |title=Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 1 |pages= 302–6 |year= 1989 |pmid= 2643102 |doi=
*cite journal | author=Sutherland GR, Baker E, Fernandez KE, "et al." |title=The gene for human interleukin 7 (IL7) is at 8q12-13 |journal=Hum. Genet. |volume=82 |issue= 4 |pages= 371–2 |year= 1989 |pmid= 2786840 |doi=
*cite journal | author=Muegge K, Vila MP, Durum SK |title=Interleukin-7: a cofactor for V(D)J rearrangement of the T cell receptor beta gene |journal=Science |volume=261 |issue= 5117 |pages= 93–5 |year= 1993 |pmid= 7686307 |doi=
*cite journal | author=Watanabe M, Ueno Y, Yajima T, "et al." |title=Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes |journal=J. Clin. Invest. |volume=95 |issue= 6 |pages= 2945–53 |year= 1995 |pmid= 7769137 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Noguchi M, Nakamura Y, Russell SM, "et al." |title=Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor |journal=Science |volume=262 |issue= 5141 |pages= 1877–80 |year= 1994 |pmid= 8266077 |doi=
*cite journal | author=Sica D, Rayman P, Stanley J, "et al." |title=Interleukin 7 enhances the proliferation and effector function of tumor-infiltrating lymphocytes from renal-cell carcinoma |journal=Int. J. Cancer |volume=53 |issue= 6 |pages= 941–7 |year= 1993 |pmid= 8473051 |doi=
*cite journal | author=Kroemer RT, Doughty SW, Robinson AJ, Richards WG |title=Prediction of the three-dimensional structure of human interleukin-7 by homology modeling |journal=Protein Eng. |volume=9 |issue= 6 |pages= 493–8 |year= 1996 |pmid= 8862549 |doi=
*cite journal | author=Kroemer RT, Richards WG |title=Homology modeling study of the human interleukin-7 receptor complex |journal=Protein Eng. |volume=9 |issue= 12 |pages= 1135–42 |year= 1997 |pmid= 9010926 |doi=
*cite journal | author=Kim JH, Loveland JE, Sitz KV, "et al." |title=Expansion of restricted cellular immune responses to HIV-1 envelope by vaccination: IL-7 and IL-12 differentially augment cellular proliferative responses to HIV-1 |journal=Clin. Exp. Immunol. |volume=108 |issue= 2 |pages= 243–50 |year= 1997 |pmid= 9158092 |doi=

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