- Marbofloxacin
-
Marbofloxacin 
Systematic (IUPAC) name 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyridol(3,2,1-ij)(4,2,1)benzoxadiazin-6 carboxylic acid Clinical data AHFS/Drugs.com International Drug Names Pregnancy cat. ? Legal status veterinary prescription only Routes oral Identifiers CAS number 115550-35-1 
ATCvet code QJ01MA93 ChemSpider 54663 UNII 8X09WU898T 
ChEMBL CHEMBL478120 Chemical data Formula C17H19FN4O4 Mol. mass 362.356 SMILES eMolecules & PubChem - InChI=1S/C17H19FN4O4/c1-19-3-5-21(6-4-19)14-12(18)7-10-13-16(14)26-9-20(2)22(13)8-11(15(10)23)17(24)25/h7-8H,3-6,9H2,1-2H3,(H,24,25)
Key:BPFYOAJNDMUVBL-UHFFFAOYSA-N
(what is this?) (verify)Marbofloxacin is a potent antibiotic of the fluoroquinolone group. It is used in veterinary medicine under the trade names Marbocyl and Zeniquin. A formulation of marbofloxacin combined with clotrimazole and dexamethasone is available under the name Aurizon (CAS number 115550-35-1).
Contents
Mechanism of action
Marbofloxacin is a quinolone, and acts by inhibiting bacterial DNA replication. It is effective against enterobacteria, Pasteurella, Pseudomonas and staphylococci.[1]
Application
Marbofloxacin can be used both orally and topically. It is particularly used for infections of the skin, respiratory system and mammary glands, as well as with urinary tract infections in dogs and cats. For dogs, a dose of approximately 2 mg/kg is used. The duration of treatment is usually at least five days, longer if there is a concurrent fungal or yeast infection.[2]
Contraindications and side effects
Marbofloxacin should usually be avoided in young animals, during pregnancy where central nervous system accumulation can occur, or when there is an existing kidney problem. Under certain conditions it can cause discomfort such as cramps, treatable with Valium. Other side effects are vomiting and anorexia.
See also
References
- ^ Le Carrou J, Laurentie M, Kobisch M, Gautier-Bouchardon AV (June 2006). "Persistence of Mycoplasma hyopneumoniae in experimentally infected pigs after marbofloxacin treatment and detection of mutations in the parC gene". Antimicrob. Agents Chemother. 50 (6): 1959–66. doi:10.1128/AAC.01527-05. PMC 1479153. PMID 16723552. http://aac.asm.org/cgi/content/full/50/6/1959.
- ^ Rougier S, Borell D, Pheulpin S, Woehrlé F, Boisramé B (October 2005). "A comparative study of two antimicrobial/anti-inflammatory formulations in the treatment of canine otitis externa". Vet. Dermatol. 16 (5): 299–307. doi:10.1111/j.1365-3164.2005.00465.x. PMID 16238809. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0959-4493&date=2005&volume=16&issue=5&spage=299.
External links
Antibacterials: nucleic acid inhibitors (J01E, J01M) Antifolates
(inhibits
purine metabolism,
thereby inhibiting
DNA and RNA synthesis)Sulfonamides
(DHPS inhibitor)Other/ungroupedCombinationsTopoisomerase
inhibitors/
quinolones/
(inhibits
DNA replication)1st g.2nd g.Ciprofloxacin# • Enoxacin‡ • Fleroxacin‡ • Lomefloxacin • Nadifloxacin • Ofloxacin • Norfloxacin • Pefloxacin • Rufloxacin3rd g.4th g.Besifloxacin • Clinafloxacin† • Garenoxacin • Gemifloxacin • Moxifloxacin • Gatifloxacin‡ • Sitafloxacin • Trovafloxacin‡/Alatrofloxacin‡ • PrulifloxacinVet.Danofloxacin • Difloxacin • Enrofloxacin • Ibafloxacin • Marbofloxacin • Orbifloxacin • Pradofloxacin • SarafloxacinRelated (DG)Anaerobic DNA
inhibitorsNitrofuran derivativesRNA synthesis Categories:- Fluoroquinolone antibiotics
- Veterinary drugs
- Piperazines
- InChI=1S/C17H19FN4O4/c1-19-3-5-21(6-4-19)14-12(18)7-10-13-16(14)26-9-20(2)22(13)8-11(15(10)23)17(24)25/h7-8H,3-6,9H2,1-2H3,(H,24,25)
Wikimedia Foundation. 2010.
