Chromatin Structure Remodeling (RSC) Complex

Chromatin Structure Remodeling (RSC) Complex

complex and is essential for mitotic growth.cite journal | author = Cairns BR, Lorch Y, Li Y, Zhang M, Lacomis L, Erdjument-Bromage H, Tempst P, Du J, Laurent B, Kornberg RD | title = RSC, an essential, abundant chromatin-remodeling complex | journal = Cell | volume = 87 | issue = 7 | pages = 1249–60 | year = 1996 | pmid = 8980231 | doi = 10.1016/S0092-8674(00)81820-6 ]

Generation of loops in dsDNA

A single molecule study using magnetic tweezers has observed that RSC generates DNA loops in vitro while simultaneously generating negative supercoils in the template.cite journal | author = Lia G, Praly E, Ferreira H, Stockdale C, Tse-Dinh YC, Dunlap D, Croquette V, Bensimon D, Owen-Hughes T | title = Direct observation of DNA distortion by the RSC complex | journal = Mol. Cell | volume = 21 | issue = 3 | pages = 417–25 | year = 2006 | pmid = 16455496 | doi = 10.1016/j.molcel.2005.12.013 ] The figure above shows three AFM images from that study. On the left, a single RSC complex is bound to the end of a dsDNA template. The center image shows a DNA loop generated by RSC. The image on the right shows a loop generated by RSC which contains supercoils.

The current model of translocation on dsDNA is shown in the figure to the right, whereby RSC binds the DNA at two locations. Hydrolysis of ATP allows the complex to translocate the DNA into a loop. RSC can release the loop either by translocating back to the original state at a comparable velocity, or by losing one of its two contacts.

RSC components

The following is list of RSC components that have been identified in yeast and the corresponding human orthologs:

See also

* SWI/SNF Nucleosome Remodeling Complex
* Transcription coregulator

References


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Chromatin structure remodeling (RSC) complex — AFM images showing single RSC complexes bound to dsDNA. The center and right images show RSC generated DNA loops (bar = 50 nm). RSC is a 17 subunit complex with the capacity to remodel the structure of chromatin. It exhibits a DNA dependent… …   Wikipedia

  • RSC — is a three letter initialism that can stand for several things:*RuneScape Community or RuneScape Classic *Chromatin Structure Remodeling (RSC) Complex *Recursive Systematic Convolutional code a type of convolutional code *Referee Stopped Contest… …   Wikipedia

  • EP300 — See also: p300 CBP coactivator family E1A binding protein p300 PDB rendering based on 1f81 …   Wikipedia

  • PCAF — K(lysine) acetyltransferase 2B PDB rendering based on 1cm0 …   Wikipedia

  • CREB-binding protein — See also: p300 CBP coactivator family CREB binding protein PDB rendering based on 1f81 …   Wikipedia

  • Nuclear receptor coactivator 2 — Rendering of 1GWQ …   Wikipedia

  • Nuclear receptor co-repressor 1 — Nuclear receptor corepressor 1 Rendering based on PDB 2EQR …   Wikipedia

  • Nuclear receptor coactivator 3 — NCOA3 activation domain 1 (AD1) bound to a portion of CBP. PDB rendering based on 1kbh …   Wikipedia

  • Coactivator (genetics) — A coactivator is a protein that increases gene expression by binding to an activator (or transcription factor) which contains a DNA binding domain. The coactivator is unable to bind DNA by itself.[1][2][3] The coactivator can enhance… …   Wikipedia

  • SWI/SNF — dependent manner, though the exact nature of this structural change is unknown.Family membersBelow is a list of yeast SWI/SNF family members and human orthologs:cite journal | author = Collingwood TN, Urnov FD, Wolffe AP | title = Nuclear… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”